ID | 13576 |
Eprint ID | 13576
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フルテキストURL | |
タイトル(別表記) | Abnormal polyunsaturated fatty acid pattern in plasma physholipiods and its clinical significance in patients with hepatocellular carcinoma snd live cirrhosis
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著者 |
横山 純子
Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry
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抄録 | The aim of present syudy is to analyze fatty acid composition in plasma phospolipids in patients with hepatocellular carcinoma (HCC) and live cirrhosis (LC) and to elucidate the significance of polunsaturated fatty acid on hepatocarcinogenesis. Arachidonic acid/Linoleic acid (AA/LA) molar ratios in plasma phosphatidylinositol in LC (1.42±0.29,p<0.01) and in HCC (1.24±0.12,p<0.001) were significantly lower than that in control subjects (2.78±0.16). The AA/LA molar ratio in plasma phoshatidylethanolamine in HCC(1.07±0.13) was significantly lower than that in control subjecls (1.94±0.21,p<0.01). The plasma lysophospatidyclholine (LysoPC) concentration in HCC (71.6±8.4nmol/ml, p<0.001) and in LC(80.9±12.0 nmol/ml, p<0.001) were siginificantly lower than that in control subjects (146.7±5.7nmol/ml). Plasma arachidonoy-LysoPC was siginificantly in HCC(3.2±0.5mol%) compared with that in LC (1.5±0.3mol%,p<0.01) and in control subjecys (1.9±0.1mol%,p<0.01). Plasma arachidonoy-LysoPC may play an importhant role in the pathophysiology of HCC patients.
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キーワード | plasma phospholipids
arachidonic acird
lysophosphatidylcholine
hepatocellular carcinoma
liver chrrhosis
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備考 | 原著論文
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発行日 | 2002-09-30
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 114巻
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号 | 2号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 145
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終了ページ | 152
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/114/2/114_2_145/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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