ID | 13573 |
Eprint ID | 13573
|
フルテキストURL | |
タイトル(別表記) | In vivo and in vitro analysis of the effect of various acid-secretion blockers on UDP-galactosyltransferase activities in rat gastric mucosa
|
著者 |
木原 康裕
Department of Medicine and Medical Science,Okayama University Graduate School of Medicine and Dentistry
|
抄録 | Gastric mucus glycoprotein is important for the protection of gastric mucosa from acid. UDP-galactosyltransfer-ase (UDP-Gal-T) is a key enzyme for the synthesis of gastric mucus glycoprotein. In this study, we investigted the effects of five acid-secretion blockers, cimetidine, ranitidine, famotidine, roxatidine and omprazole on the UDP-Gal-T activity in rat gastric mucosa to clarify the interaction of the acid-secretion blocker and the gastric mucosal barrier. Intraperitoneal administration of these drugs to rat increased pH of the gastric mucosal suface and significantly decreased the gastric UDP-Gal-T activies. When we administered citrate phoshate buffer (pH 2) to the rat stomach to inhibit the change of gastric pH induced by the acid-secretion blockers, the effecer of famotidine, roxatidine and omeprazole on UDP-Gal T activties were abolished, but cimetidine and ranitidine significantly decreased the enzyme activiyty When we incubated the acid-secretion blockers with the homogenates of ral gastric mucosa, cimetidine and ranitidine significantly dereased UDP-Gal-T activites, whreas the other drugs showed no apparent influence on the enzyme sctivity. These findins suggest that the acid-secretion blockers decrease gastric mucin synthesis via the increase of the intragastric pH.In addition, among the acid-secretion blockers stydied here, cimetidine and rantidine also have direct inhibitory effects on the gastric UDP-Gal-T activity.
|
キーワード | mucin
galactosyltransferase
H2-receptor antagonist
proton pump inhibitor
|
備考 | 原著論文
|
発行日 | 2002-09-30
|
出版物タイトル |
岡山医学会雑誌
|
出版物タイトル(別表記) | Journal of Okayama Medical Association
|
巻 | 114巻
|
号 | 2号
|
出版者 | 岡山医学会
|
出版者(別表記) | Okayama Medical Association
|
開始ページ | 139
|
終了ページ | 144
|
ISSN | 0030-1558
|
NCID | AN00032489
|
資料タイプ |
学術雑誌論文
|
オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/114/2/114_2_139/_article/-char/ja/
|
関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
|
言語 |
日本語
|
著作権者 | 岡山医学会
|
論文のバージョン | publisher
|
査読 |
有り
|
Eprints Journal Name | joma
|