ID | 17245 |
Eprint ID | 17245
|
フルテキストURL | |
タイトル(別表記) | The effects of various heavy metal ions (such as Hg(2+), Cd(2+), Cu(2+) and Zn(2+)) on mitochondrial membrane with specific reference to K(+) compart mentation
|
著者 |
長谷川 亨
岡山大学医学部公衆衛生学教室
|
抄録 | The effects of various heavy metal ions such as Hg(2+), Cd(2+), Cu(2+) and Zn(2+) on mitochondrial membrane were investigated and the following results were obtained; 1) Hg(2+), Cd(2+), Cu(2+) and Zn(2+) released the potassium ion from the mitochondria with the increasing level of an affinity to SH compounds. 2) The release of K(+) by Cd(2+) and Zn(2+) was inhibited in the presence of Mg(2+), but the release of K(+) by Hg(2+) and Cu(2+) was not affected. 3) In the presence of ImM DTT, the release of K(+) by all of these metal ions was completely inhibited.4) The K+ release by Hg(2+) and Cu(2+) was inhibited by DTNB or PCMB which bound prefencially the thiol component of membrane protein, but the release by Cd(2+) and Zn(2+) was not inhibited by these reagents. 5) The release of K(+) decoupled the oxidative phosphorylation by treatment of the heavy metal ions.
|
発行日 | 1977-12-30
|
出版物タイトル |
岡山医学会雑誌
|
出版物タイトル(別表記) | Journal of Okayama Medical Association
|
巻 | 89巻
|
号 | 11-12号
|
出版者 | 岡山医学会
|
出版者(別表記) | Okayama Medical Association
|
開始ページ | 1487
|
終了ページ | 1494
|
ISSN | 0030-1558
|
NCID | AN00032489
|
資料タイプ |
学術雑誌論文
|
オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/89/11-12/89_11-12_1487/_article/-char/ja/
|
関連URL | http://www.okayama-u.ac.jp/user/oma/
|
言語 |
日本語
|
著作権者 | 岡山医学会
|
論文のバージョン | publisher
|
査読 |
有り
|
Eprints Journal Name | joma
|