ID | 58212 |
Sort Key | 5
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タイトル(別表記) | Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia
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フルテキストURL | |
著者 |
三浦 公
津山中央病院 内科
豊川 達也
福山医療センター 消化器内科
竹中 龍太
津山中央病院 内科
井上 雅文
岡山赤十字病院 消化器内科
伊藤 守
岡山済生会総合病院 内科
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抄録 | To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety.
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キーワード | 機能性ディスペプシア (functional dyspepsia)
ヘリコバクター・ピロリ (Helicobacter pylori)
プロトンポンプ阻害剤 (proton pomp inhibitor)
消化管運動機能改善剤 (acotiamide)
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備考 | 原著(Original)
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出版物タイトル |
岡山医学会雑誌
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発行日 | 2019-12-02
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巻 | 131巻
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号 | 3号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 139
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終了ページ | 143
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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関連URL | isVersionOf https://doi.org/10.4044/joma.131.139
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OAI-PMH Set |
岡山大学
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言語 |
日本語
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著作権者 | Copyright (c) 2019 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
NAID | |
Eprints Journal Name | joma
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