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ID 60833
フルテキストURL
著者
Fujiwara, Tomohiro Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences ORCID Kaken ID
Tsuda, Yusuke The Royal Orthopaedic Hospital NHS Foundation Trust
Le Nail, Louis-Romée The Royal Orthopaedic Hospital NHS Foundation Trust
Evans, Scott The Royal Orthopaedic Hospital NHS Foundation Trust
Gregory, Jonathan The Royal Orthopaedic Hospital NHS Foundation Trust
Tillman, Roger The Royal Orthopaedic Hospital NHS Foundation Trust
Abudu, Adesegun The Royal Orthopaedic Hospital NHS Foundation Trust
抄録
Aims
The existing clinical guidelines do not describe a clear indication for adjuvant radiotherapy (RT) in the treatment of superficial soft tissue sarcomas (STSs). We aimed to determine the efficacy of adjuvant RT for superficial STSs.
Methods
We retrospectively studied 304 patients with superficial STS of the limbs and trunk who underwent surgical resection at a tertiary sarcoma centre. The efficacy of RT was investigated according to the tumour size and grade: group 1, ≤ 5 cm, low grade; group 2, ≤ 5cm, high grade; group 3, > 5 cm, low grade; group 4, > 5 cm, high grade.
Results
The five- and ten-year local recurrence-free survival (LRFS) for all patients was 88% and 81%, respectively. While the efficacy of adjuvant RT was not proven in local control of all patients (five-year LRFS; RT+, 90% versus RT-, 83%; p = 0.074), the LRFS was significantly improved by adjuvant RT in group 2 (five-year LRFS; RT+, 96% versus RT-, 82%; p = 0.019), and group 4 (five-year LRFS; RT+, 87% versus RT-, 73%; p = 0.027). In groups 2 and 4, adjuvant RT significantly reduced the LR risk if the resection margin was clear but less than 5 mm; the LR rate was 7% with adjuvant RT compared with 26% with surgery alone (p = 0.003). There was no statistical relationship with the use of adjuvant RT and survival in every group.
Conclusion
Adjuvant RT reduces the risk of local recurrence in patients with superficial high-grade STS regardless of tumour size, especially when resection margin is less than 5 mm.
発行日
2020-07-31
出版物タイトル
Bone and Joint Journal
102-B巻
8号
出版者
British Editorial Society of Bone and Joint Surgery
開始ページ
1088
終了ページ
1094
ISSN
2049-4394
NCID
AA12602094
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
論文のバージョン
author
PubMed ID
DOI
Web of Science KeyUT
関連URL
is VersionOf https://doi.org/10.1302/0301-620X.102B8.BJJ-2020-0043.R1