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Ueno, Hiroshi Department of Medical Technology, Kawasaki University of Medical Welfare
Shimada, Atsumi Division of Food and Nutrition, Nakamura Gakuen University Junior College
Suemitsu, Shunsuke Department of Psychiatry, Kawasaki Medical School
Murakami, Shinji Department of Psychiatry, Kawasaki Medical School
Kitamura, Naoya Department of Psychiatry, Kawasaki Medical School
Wani, Kenta Department of Psychiatry, Kawasaki Medical School
Matsumoto, Yosuke Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University publons researchmap
Okamoto, Motoi Department of Medical Technology, Graduate School of Health Sciences, Okayama University Kaken ID publons researchmap
Fujiwara, Yuko Department of Health and Sports Science, Kawasaki University of Medical Welfare researchmap
Ishihara, Takeshi Department of Psychiatry, Kawasaki Medical School
Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.
© 2019 The Authors.
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