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ID 48284
フルテキストURL
著者
Yamamoto, Dai Department of Hygiene, Sapporo Medical University School of Medicine
Ghosh, Souvik Department of Hygiene, Sapporo Medical University School of Medicine
Kuzuya, Mitsutaka Okayama Prefectural Institute for Environmental Science and Public Health
Wang, Yuan-Hong Wuhan Centers for Disease Prevention and Control
Zhou, Xuan Wuhan Centers for Disease Prevention and Control
Chawla-Sarkar, Mamta National Institute of Cholera and Enteric Diseases
Paul, Shyamal Kumar Mymensingh Medical College
Ishino, Masaho Department of Hygiene, Sapporo Medical University School of Medicine
Kobayashi, Nobumichi Department of Hygiene, Sapporo Medical University School of Medicine
抄録
Group C rotavirus (GCRV) is distributed worldwide as an enteric pathogen in humans and animals. However, to date, whole-genome sequences are available only for a human strain (Bristol) and a porcine strain (Cowden). To investigate the genetic diversity of human GCRVs, nearly full-length sequences of all 11 RNA segments were determined for human GCRVs detected recently in India (v508), Bangladesh (BS347), China (Wu82 and YNR001) and Japan (OH567 and BK0830) and analysed phylogenetically with sequence data for GCRVs published previously. All the RNA segments of human GCRV strains except for the VP3 gene showed high levels of conservation (>93 % nucleotide sequence identity, >92 % amino acid sequence identity), belonging to a single genetic cluster distinct from those of animal GCRVs. In contrast, the VP3 genes of human GCRVs could be discriminated into two clusters, designated M2 and M3, that were distinguished phylogenetically from those of porcine and bovine GCRVs (clusters M1 and M4, respectively). Between M2 and M3, amino acid sequence identity of the VP3 gene was 84.1–84.7 %, whereas high identities were observed within each cluster (92.3–97.6 % for M2, 98.2–99.3 % for M3). Sequence divergence among the four VP3 clusters was observed throughout the amino acid sequence except for conserved motifs, including those possibly related to enzyme functions of VP3. The presence of obvious genetic diversity only in the VP3 gene among human GCRVs suggested that either the M2 or M3 VP3 gene of human GCRVs might have been derived through reassortment from an animal GCRV or from an unidentified human GCRV strain belonging to a novel genogroup.
発行日
2011-02
出版物タイトル
Journal of General Virology
92巻
2号
開始ページ
361
終了ページ
369
ISSN
0022-1317
NCID
AA00698722
資料タイプ
学術雑誌論文
プロジェクト
インド感染症共同研究
オフィシャル URL
http://vir.sgmjournals.org/content/92/2/361
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2011 SGM
論文のバージョン
author
査読
有り
DOI
PubMed ID
Web of Sience KeyUT