ID | 34163 |
フルテキストURL | |
著者 |
Miyoshi, Shin-ichi
Okayama University
Watanabe, Hirofumi
Okayama University
Kawase, Tomoka
Okayama University
Shinoda, Sumio
Okayama University
|
抄録 | Vibrio vulnificus is an opportunistic human pathogen causing septicemia, and the infection is characterized by formation of the edematous skin lesions on limbs. This pathogenic species secretes a thermolysin-like metalloprotease as a virulence determinant. The metalloprotease was confirmed to activate human factor XII-plasma kallikrein-kinin cascade that results in liberation of bradykinin, a chemical mediator enhancing the vascular permeability, from high-molecular weight kininogen. Namely, the metalloprotease showed to generate active fragments by cleavage of Arg-Ile, Arg-Val or Gly-Leu peptide bond in human zymogens (plasma prekallikrein and factor XII). In spite of induction of the sufficient vascular permeability-enhancing and edema-forming reaction in the guinea pig model, a serine protease from V. parahaemolyticus, a human pathogen causing primarily watery diarrhea, showed far less ability to activate and to cleave the human zymogens. These results in part may explain why only V. vulnificus often causes serious edematous skin damages in humans. |
キーワード | vibrio vulnificus
vibrio parahaemolyticus
protease
factor XII
plasma prekallikrein
|
備考 | Digital Object Identifer:10.1016/j.toxicon.2004.08.013
Published with permission from the copyright holder. This is the institute's copy, as published in Toxicon, December 2004, Volume 44, Issue 8, Pages 887-893. Publisher URL:http://dx.doi.org/10.1016/j.toxicon.2004.08.013 Direct access to Thomson Web of Science record Copyright © 2004 Elsevier Ltd. All rights reserved. |
発行日 | 2004-12
|
出版物タイトル |
Toxicon
|
巻 | 44巻
|
号 | 8号
|
開始ページ | 887
|
終了ページ | 893
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
査読 |
有り
|
DOI | |
Web of Science KeyUT | |
Submission Path | pharmacology_general/2
|