吉田龍一

Usefulness of Middle Colic Artery Transposition Technique for Hepatic Arterial Reconstruction in Conversion Surgery for an Initially Unresectable, Locally Advanced Pancreatic Cancer

JaLCDOI	10.18926/AMO/62410
フルテキストURL	75_4_543.pdf
著者	Yoshida, Ryuichi\| Yagi, Takahito\| Yasui, Kazuya\| Umeda, Yuzo\| Yoshida, Kazuhiro\| Fuji, Tomokazu\| Takagi, Kosei\| Kumano, Kenjiro\| Yoshimoto, Masashi\| Fujiwara, Toshiyoshi\|
抄録	The outcomes of pancreatectomy with resection and reconstruction of the involved arteries for locally advanced pancreatic cancer following chemotherapy have improved in recent years. In pancreatic head cancers in which there is contact with the common and proper hepatic arteries, margin-negative resection requires pancreati-coduodenectomy, with the resection of these arteries and the restoration of hepatic arterial flow. Here, we describe a middle colic artery transposition technique in hepatic arterial reconstruction during pancreatoduo-denectomy for an initially unresectable locally advanced pancreatic cancer. This technique was effective and may provide a new option for hepatic artery reconstruction in such cases.
キーワード	hepatic artery locally advanced pancreatic cancer middle colic artery pancreatoduodenectomy reconstruction technique
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	543
終了ページ	548
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511625
Web of Science KeyUT	000696755800004
NAID	120007146036

Gastroenteropancreatic neuroendocrine tumor of the accessory papilla of the duodenum: a case report

フルテキストURL	fulltext.pdf
著者	Takagi, Kosei\| Umeda, Yuzo\| Yoshida, Ryuichi\| Yoshida, Kazuhiro\| Yasui, Kazuya\| Sato, Hiroki\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
キーワード	Accessory papilla of the duodenum Neuroendocrine tumor Carcinoid tumor
発行日	2021-06-30
出版物タイトル	Surgical Case Reports
巻	7巻
号	1号
出版者	Springer
開始ページ	156
ISSN	2198-7793
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021.
論文のバージョン	publisher
PubMed ID	34191176
DOI	10.1186/s40792-021-01241-4
Web of Science KeyUT	000671314900002
関連URL	isVersionOf https://doi.org/10.1186/s40792-021-01241-4

Surgical training model and safe implementation of robotic pancreatoduodenectomy in Japan: a technical note

フルテキストURL	fulltext.pdf
著者	Takagi, Kosei\| Umeda, Yuzo\| Yoshida, Ryuichi\| Yagi, Takahito\| Fujiwara, Toshiyoshi\| Zureikat, Amer H.\| Hogg, Melissa E.\| Koerkamp, Bas Groot\|
キーワード	Pancreatoduodenectomy Robotic surgery Training
発行日	2021-02-19
出版物タイトル	World Journal of Surgical Oncology
巻	19巻
号	1号
出版者	BMC
開始ページ	55
ISSN	1477-7819
NCID	AA12048269
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2021
論文のバージョン	publisher
PubMed ID	33608019
DOI	10.1186/s12957-021-02167-9
Web of Science KeyUT	000621197800003
関連URL	isVersionOf https://doi.org/10.1186/s12957-021-02167-9

Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation

フルテキストURL	fulltext.pdf
著者	Ito, Atene\| Kagawa, Shunsuke\| Sakamoto, Shuichi\| Kuwada, Kazuya\| Kajioka, Hiroki\| Yoshimoto, Masashi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
発行日	2021-01-28
出版物タイトル	BMC Cancer
巻	21巻
号	1号
出版者	BMC
開始ページ	102
ISSN	1471-2407
NCID	AA12034763
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2021
論文のバージョン	publisher
PubMed ID	33509150
DOI	10.1186/s12885-021-07816-6
Web of Science KeyUT	000615987400002
関連URL	isVersionOf https://doi.org/10.1186/s12885-021-07816-6

Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

フルテキストURL	fulltext.pdf Figures.pdf Suppl_Material_Methods.pdf Suppl_Figures.pdf Legend_suppl_figures.pdf Suppl_Table.pdf
著者	Kajioka, Hiroki\| Kagawa, Shunsuke\| Ito, Atene\| Yoshimoto, Masashi\| Sakamoto, Shuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Umeda, Yuzo\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model
備考	This fulltext is available in January, 2022.\|
発行日	2021-01-28
出版物タイトル	Cancer Letters
巻	497巻
出版者	Elsevier
開始ページ	1
終了ページ	3
ISSN	0304-3835
NCID	AA00598513
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	33065249
DOI	10.1016/j.canlet.2020.10.015
Web of Science KeyUT	000596072900001
関連URL	isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015

Hemobilia after bile duct resection: perforation of pseudoaneurysm into intra-pancreatic remnant bile duct: a case report

フルテキストURL	fulltext.pdf
著者	Yoshida, Kazuhiro\| Umeda, Yuzo\| Iwamuro, Masaya\| Matsumoto, Kazuyuki\| Kato, Hironari\| Uka, Mayu\| Matsui, Yusuke\| Yoshida, Ryuichi\| Kuise, Takashi\| Yasui, Kazuya\| Takagi, Kosei\| Araki, Hiroyuki\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
キーワード	Hemobilia Bile duct resection Hepatectomy Endoscopic balloon tamponade Case report
発行日	2020-12-01
出版物タイトル	BMC Surgery
巻	20巻
号	1号
出版者	BMC
開始ページ	307
ISSN	1471-2482
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2020.
論文のバージョン	publisher
PubMed ID	33261613
DOI	10.1186/s12893-020-00981-8
Web of Science KeyUT	000595042700001
関連URL	isVersionOf https://doi.org/10.1186/s12893-020-00981-8

A novel modified hanging maneuver in laparoscopic left hemihepatectomy

フルテキストURL	fulltext.pdf
著者	Takagi, Kosei\| Umeda, Yuzo\| Kuise, Takashi\| Yoshida, Ryuichi\| Yoshida, Kazuhiro\| Yasui, Kazuya\| Tani, Yuma\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
キーワード	Hanging maneuver Laparoscopic Liver resection
発行日	2020-10-08
出版物タイトル	International Journal of Surgery Case Reports
巻	76巻
出版者	Elsevier
開始ページ	251
終了ページ	253
ISSN	2210-2612
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Author(s).
論文のバージョン	publisher
PubMed ID	33053483
DOI	10.1016/j.ijscr.2020.10.002
関連URL	isVersionOf https://doi.org/10.1016/j.ijscr.2020.10.002

Efficacy and safety of scheduled early endoscopic ultrasonography‐guided ethanol reinjection for patients with pancreatic neuroendocrine tumors: Prospective pilot study

フルテキストURL	fulltext.pdf Figures.pdf Supplemental Figures.pdf
著者	Matsumoto, Kazuyuki\| Kato, Hironari\| Kawano, Seiji\| Fujiwara, Hiroyasu\| Nishida, Kenji\| Harada, Ryo\| Fujii , Masakuni\| Yoshida, Ryuichi\| Umeda, Yuzo\| Hinotsu, Shiro\| Yagi , Takahito\| Okada, Hiroyuki\|
キーワード	ethanol injection EUS‐guided therapy pancreatic neuroendocrine tumor scheduled therapy small size
備考	This is the peer reviewed version of the following article: Kazuyuki Matsumoto et. al. Efficacy and safety of scheduled early endoscopic ultrasonography‐guided ethanol reinjection for patients with pancreatic neuroendocrine tumors: Prospective pilot study. Digestive Endoscopy (2020) 32(3), 425-430, which has been published in final form at https://doi.org/10.1111/den.13552\|. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.\|
発行日	2020-03
出版物タイトル	Digestive Endoscopy
巻	32巻
号	3号
出版者	Wiley
開始ページ	425
終了ページ	430
ISSN	0915-5635
NCID	AA10907137
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31580507
DOI	10.1111/den.13552
Web of Science KeyUT	000494577300001
関連URL	isVersionOf https://doi.org/10.1111/den.13552

The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm

フルテキストURL	fulltext.pdf
著者	Miyamoto, Kazuya\| Matsumoto, Kazuyuki\| Kato, Hironari\| Yoshida, Ryuichi\| Umeda, Yuzo\| Inoue, Hirohumi\| Tanaka, Takehiro\| Matsumi, Akihiro\| Saragai, Yosuke\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Uchida, Daisuke\| Tomoda, Takeshi\| Horiguchi, Shigeru\| Yagi, Takahito\| Okada, Hiroyuki\|
キーワード	IPMN PJC LBC BD SurePath
発行日	2020-09-29
出版物タイトル	BMC Gastroenterology
巻	20巻
号	1号
出版者	BMC
開始ページ	319
ISSN	1471-230X
NCID	AA12034934
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	32993498
DOI	10.1186/s12876-020-01465-y
Web of Science KeyUT	000576989100004
関連URL	isVersionOf https://doi.org/10.1186/s12876-020-01465-y

Laparoscopic liver resection of segment seven: A case report and review of surgical techniques

フルテキストURL	fulltext.pdf
著者	Takagi, Kosei\| Kuise, Takashi\| Umeda, Yuzo\| Yoshida, Ryuichi\| Teraishi, Fuminori\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
キーワード	Laparoscopic Liver Segment seven
発行日	2020
出版物タイトル	International Journal of Surgery Case Reports
巻	73巻
出版者	Elsevier
開始ページ	168
終了ページ	171
ISSN	2210-2612
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Author(s).
論文のバージョン	publisher
PubMed ID	32688239
DOI	10.1016/j.ijscr.2020.06.107
Web of Science KeyUT	000558775100010
関連URL	isVersionOf https://doi.org/10.1016/j.ijscr.2020.06.107

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

フルテキストURL	fulltext.pdf
著者	Koujima, Takeshi\| Tazawa, Hiroshi\| Ieda, Takeshi\| Araki, Hiroyuki\| Fushimi, Takuro\| Shoji, Ryohei\| Kuroda, Shinji\| Kikuchi, Satoru\| Yoshida, Ryuichi\| Umeda, Yuzo\| Teraishi, Fuminori\| Urata, Yasuo\| Mizuguchi, Hiroyuki\| Fujiwara, Toshiyoshi\|
発行日	2020-06-26
出版物タイトル	Molecular Therapy - Oncolytics
巻	17巻
出版者	Cell Press
開始ページ	107
終了ページ	117
ISSN	2372-7705
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Author(s).
論文のバージョン	publisher
PubMed ID	32322667
DOI	10.1016/j.omto.2020.03.016
Web of Science KeyUT	000544101600010
関連URL	isVersionOf https://doi.org/10.1016/j.omto.2020.03.016

Pediatric Living Donor Liver Transplantation for Congenital Absence of the Portal Vein With Pulmonary Hypertension: A Case Report

フルテキストURL	fulltext.pdf
著者	Matsumoto, Naohisa\| Matsusaki, Takashi\| Hiroi, Kazumasa\| Kaku, Ryuji\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Morimatsu, Hiroshi\|
備考	11th Congress of the Andalusian-Society-of-Organ-and-Tissue-Transplantation (SATOT)\|
発行日	2020-03-31
出版物タイトル	Transplantation Proceedings
巻	52巻
号	2号
出版者	Elsevier
開始ページ	630
終了ページ	633
ISSN	00411345
NCID	AA00868957
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors. Published by Elsevier Inc.
論文のバージョン	publisher
PubMed ID	32029317
DOI	10.1016/j.transproceed.2019.11.032
Web of Science KeyUT	000518473000059
関連URL	isVersionOf https://doi.org/10.1016/j.transproceed.2019.11.032

The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer

フルテキストURL	JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg
著者	Matsumoto, Kazuyuki\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Takaki, Akinobu\| Takahara, Masahiro\| Tanaka, Noriyuki\| Kato, Hironari\| Horiguchi, Shigeru\| Yoshida, Ryuichi\| Umeda, Yuzo\| Fushimi, Soichiro\| Yagi, Takahito\| Matsukawa, Akihiro\| Okada, Hiroyuki\|
キーワード	Immunohistochemistry PD-L1 Pancreatic cancer
備考	This fulltext will be available in Apr 2020\|
発行日	2019-04-29
出版物タイトル	Journal of Gastroenterology
巻	54巻
号	11号
開始ページ	1019
終了ページ	1028
ISSN	09441174
NCID	AA10988015
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31032528
DOI	10.1007/s00535-019-01586-6
Web of Science KeyUT	000492169400008
関連URL	isVersionOf https://doi.org/10.1007/s00535-019-01586-6

Intraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer

フルテキストURL	OncoImmunol_8_12_1671760.pdf
著者	Sakamoto, Shuichi\| Kagawa, Shunsuke\| Kuwada, Kazuya\| Ito, Atene\| Kajioka, Hiroki\| Kakiuchi, Yoshihiko\| Watanabe, Megumi\| Kagawa, Tetsuya\| Yoshida, Ryuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
発行日	2019-10-22
出版物タイトル	OncoImmunology
巻	8巻
号	12号
出版者	TAYLOR & FRANCIS
開始ページ	e1671760
ISSN	2162402X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Author(s).
論文のバージョン	publisher
DOI	10.1080/2162402X.2019.1671760
Web of Science KeyUT	000494085400001
関連URL	isVersionOf https://doi.org/10.1080/2162402X.2019.1671760

Living Donor Liver Transplantation for Acute Liver Failure : Comparing Guidelines on the Prediction of Liver Transplantation

JaLCDOI	10.18926/AMO/55435
フルテキストURL	71_5_381.pdf
著者	Yoshida, Kazuhiro\| Umeda, Yuzo\| Takaki, Akinobu\| Nagasaka, Takeshi\| Yoshida, Ryuichi\| Nobuoka, Daisuke\| Kuise, Takashi\| Takagi, Kosei\| Yasunaka, Tetsuya\| Okada, Hiroyuki\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
抄録	Determining the indications for and timing of liver transplantation (LT) for acute liver failure (ALF) is essential. The King’s College Hospital (KCH) guidelines and Japanese guidelines are used to predict the need for LT and the outcomes in ALF. These guidelines’ accuracy when applied to ALF in different regional and etiological backgrounds may differ. Here we compared the accuracy of new (2010) Japanese guidelines that use a simple scoring system with the 1996 Japanese guidelines and the KCH criteria for living donor liver transplantation (LDLT). We retrospectively analyzed 24 adult ALF patients (18 acute type, 6 sub-acute type) who underwent LDLT in 1998-2009 at our institution. We assessed the accuracies of the 3 guidelines’ criteria for ALF. The overall 1-year survival rate was 87.5%. The new and previous Japanese guidelines were superior to the KCH criteria for accurately predicting LT for acute-type ALF (72% vs. 17%). The new Japanese guidelines could identify 13 acute-type ALF patients for LT, based on the timing of encephalopathy onset. Using the previous Japanese guidelines, although the same 13 acute-type ALF patients (72%) had indications for LT, only 4 patients were indicated at the 1st step, and it took an additional 5 days to decide the indication at the 2nd step in the other 9 cases. Our findings showed that the new Japanese guidelines can predict the indications for LT and provide a reliable alternative to the previous Japanese and KCH guidelines.
キーワード	living donor liver transplantation acute liver failure fulminant hepatic failure
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2017-10
巻	71巻
号	5号
出版者	Okayama University Medical School
開始ページ	381
終了ページ	390
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29042695

Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Liver Transplantation

著者	Takagi, Kosei\| Yagi, Takahito\| Shinoura, Susumu\| Umeda, Yuzo\| Yoshida, Ryuichi\| Nobuoka, Daisuke\| Watanabe, Nobuyuki\| Kuise, Takashi\| Fuji, Tomokazu\| Araki, Hiroyuki\| Fujiwara, Toshiyoshi\|
発行日	2017-02
出版物タイトル	Acta Medica Okayama
巻	71巻
号	1号
資料タイプ	学術雑誌論文
JaLCDOI	10.18926/AMO/54830

Sarcopenia and American Society of Anesthesiologists Physical Status in the Assessment of Outcomes of Hepatocellular Carcinoma Patients Undergoing Hepatectomy

JaLCDOI	10.18926/AMO/54594
フルテキストURL	70_5_363.pdf
著者	Takagi, Kosei\| Yagi, Takahito\| Yoshida, Ryuichi\| Shinoura, Susumu\| Umeda, Yuzo\| Nobuoka, Daisuke\| Kuise, Takashi\| Watanabe, Nobuyuki\| Fujiwara, Toshiyoshi\|
抄録	Sarcopenia following liver surgery has been reported as a predictor of poor prognosis. Here we investigated predictors of outcomes in patients with hepatocellular carcinoma (HCC) and attempted to establish a new comprehensive preoperative assessment protocol. We retrospectively analyzed the cases of 254 patients who underwent curative hepatectomy for HCC with Child-Pugh classification A at our hospital between January 2007 and December 2013. Sarcopenia was evaluated by computed tomography measurement. The influence of sarcopenia on outcomes was evaluated. We used multivariate analyses to assess the impact of prognostic factors associated with outcomes, including sarcopenia. Of the 254 patients, 118 (46.5%) met the criteria for sarcopenia, and 32 had an American Society of Anesthesiologists (ASA) physical status ≥3. The sarcopenic group had a significantly lower 5-year overall survival rate than the non-sarcopenic group (58.2% vs. 82.4% , p＝0.0002). In multivariate analyses of prognostic factors, sarcopenia was an independent predictor of poor survival (hazard ratio [HR]＝2.28, p＝0.002) and poor ASA status (HR＝3.17, p＝0.001). Sarcopenia and poor ASA status are independent preoperative predictors for poor outcomes after hepatectomy. The preoperative identification of sarcopenia and ASA status might enable the development of comprehensive approaches to assess surgical eligibility.
キーワード	sarcopenia American Society of Anesthesiologists physical status hepatectomy hepatocellular carcinoma prognostic factor
Amo Type	Original Articles
出版物タイトル	Acta Medica Okayama
発行日	2016-10
巻	70巻
号	5号
出版者	Okayama University Medical School
開始ページ	363
終了ページ	370
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27777428
Web of Science KeyUT	000388098700005

Surgical Outcome of Patients Undergoing Pancreaticoduodenectomy: Analysis of a 17-Year Experience at a Single Center

JaLCDOI	10.18926/AMO/54419
フルテキストURL	70_3_197.pdf
著者	Takagi, Kosei\| Yagi, Takahito\| Yoshida, Ryuichi\| Shinoura, Susumu\| Umeda, Yuzo\| Nobuoka, Daisuke\| Kuise, Takashi\| Watanabe, Nobuyuki\| Sui, Kenta\| Fuji, Tomokazu\| Fujiwara, Toshiyoshi\|
抄録	The operative mortality and morbidity of pancreaticoduodenectomy (PD) remain high. We analyzed PD patientsʼ clinical characteristics and surgical outcomes and discuss how PD clinical outcomes could be improved. We retrospectively reviewed the cases of 400 patients who underwent a PD between January 1998 and April 2014 at Okayama University Hospital, a very-high-volume center. We identified and compared the clinical outcomes between two time periods (period 1: 1998-2006 vs. period 2: 2007-2014). The total postoperative mortality and major complication rates were 0.75 and 15.8 , respectively, and the median postoperative length of stay (LOS) was 32 days. Subsequently, patients who underwent a PD during period 2 had a significantly shorter LOS than those who underwent a PD during period 1 (29 days vs. 38.5 days, p＜0.001). The incidence of mortality and major complications did not differ between the two periods. In our multivariate analysis, period 1 was an independent factor associated with a long LOS (p＜0.001). The improvement of the surgical procedure and perioperative care might be related to the shorter LOS in period 2 and ot the consistently maintained low mortality rate after PD. The development of multimodal strategies to accelerate postoperative recovery may further improve PDʼs clinical outcomes.
キーワード	pancreaticoduodenectomy surgical outcome mortality major complication length of stay
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-06
巻	70巻
号	3号
出版者	Okayama University Medical School
開始ページ	197
終了ページ	203
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27339209
Web of Science KeyUT	000379406100007

Hepatitis C Virus-specific T-cell Response Correlates with Hepatitis Activity and Donor IL28B Genotype Early after Liver Transplantation

JaLCDOI	10.18926/AMO/52898
フルテキストURL	68_5_291.pdf
著者	Tsuzaki, Ryuichiro\| Takaki, Akinobu\| Yagi, Takahito\| Ikeda, Fusao\| Koike, Kazuko\| Iwasaki, Yoshiaki\| Shiraha, Hidenori\| Miyake, Yasuhiro\| Sadamori, Hiroshi\| Shinoura, Susumu\| Umeda, Yuzo\| Yoshida, Ryuichi\| Nobuoka, Daisuke\| Utsumi, Masashi\| Nakayama, Eiichi\| Fujiwara, Toshiyoshi\| Yamamoto, Kazuhide\|
抄録	It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At＞3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect.
キーワード	interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-10
巻	68巻
号	5号
出版者	Okayama University Medical School
開始ページ	291
終了ページ	302
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25338486
Web of Science KeyUT	000343269300006
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/53129

Living Donor Liver Transplantation to a Survivor of LiverResection for Hepatocellular Carcinoma with Major Portal Vein Invasion

JaLCDOI	10.18926/AMO/49671
フルテキストURL	67_2_117.pdf
著者	Sadamori, Hiroshi\| Yagi, Takahito\| Shinoura, Susumu\| Umeda, Yuzo\| Yoshida, Ryuichi\| Sato, Daisuke\| Nobuoka, Daisuke\| Utsumi, Masashi\| Fujiwara, Toshiyoshi\|
抄録	We present a case of living donor liver transplantation to a 3-year disease-free survivor of liver resection for hepatocellular carcinoma (HCC) with major portal vein invasion. A 48-year-old man had HCC in the right lobe with a portal venous tumor thrombus extending into the left portal vein. An extended right lobectomy with thrombectomy was performed to remove the thrombus. Three years after liver resection, the patient experienced liver failure, with massive ascites and jaundice due to the formation of a thrombus in the main and left portal veins. During the 3 years after liver resection, no metastasis or recurrence of HCC had been detected, and tumor markers had been within normal ranges. The portal venous thrombus did not show any arterial enhancement under contrast-enhanced computed tomography, suggesting that the co-existence of any HCC component in the portal venous thrombus may have been negative. Based on these findings, living donor liver transplantation was performed using a right lobe graft from the patientʼs son. The patient is alive at 87 months after the transplantation, with no evidence of HCC recurrence.
キーワード	living donor liver transplantation hepatocellular carcinoma portal vein invasion liver resection
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2013-04
巻	67巻
号	2号
出版者	Okayama University Medical School
開始ページ	117
終了ページ	121
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23603929
Web of Science KeyUT	000317801700007

吉田 龍一