ID | 52036 |
フルテキストURL | |
著者 |
Maki, Yuho
Okayama Univ Hosp, Dept Thorac Surg
Ichimura, Kouichi
Okayama Univ Hosp, Dept Pathol
Furukawa, Masashi
Okayama Univ Hosp, Dept Thorac Surg
Muraoka, Takayuki
Okayama Univ Hosp, Dept Thorac Surg
Tanaka, Norimitsu
Okayama Univ Hosp, Dept Thorac Surg
Ueno, Tsuyoshi
Okayama Univ Hosp, Dept Thorac Surg
Asano, Hiroaki
Okayama Univ Hosp, Dept Thorac Surg
Kaken ID
Toyooka, Shinichi
Okayama Univ Hosp, Dept Thorac Surg
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抄録 | High expression levels of glucose transporter isoform 1 (GLUT1) and Ki-67 are reportedly associated with malignancy-related clinicopathological factors in malignant tumors. Recently, a new histological IASLC/ATS/ERS classification for lung adenocarcinoma was proposed. In this study, we investigated the clinicopathological impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma classified according to the IASLC/ATS/ERS classification. One hundred and five patients with completely resected stage IA lung adenocarcinoma were retrospectively classified into two groups, a 'non-invasive type' (n=31) or an 'invasive type' (n=74), based on the IASLC/ATS/ERS classification. GLUT1 and Ki-67 expression status was evaluated using immunohistochemistry. The epidermal growth factor receptor (EGFR) and KRAS mutation status was determined using PCR-based assays. Positive GLUT1 and Ki-67 expression and EGFR and KRAS mutations were detected in 28 (27%), 33 (31%), 51 (49%) and 5 (8%) cases, respectively. Positive GLUT1 expression was significantly associated with a wild-type EGFR and mutant KRAS status. A multivariate analysis revealed that positive GLUT1 expression was independently associated with the 'invasive type'. In multivariate analyses for overall survival (OS) and disease-free survival (DFS), positive Ki-67 and GLUT1 expression was the only independent factor for a poor OS (P=0.012) and DFS (P=0.040), respectively. In addition, when stratified according to the GLUT1 and Ki-67 status, double-positive cases had the poorest DFS and OS times, compared with the other categories. Positive GLUT1 expression is associated with the invasive character of early-stage lung adenocarcinoma and with early disease relapse. Our results strongly suggest that GLUT1 and Ki-67 play important roles in acquiring biological malignant potential in early-stage lung adenocarcinoma.
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キーワード | early-stage lung adenocarcinoma
glucose transporter isoform 1
Ki-67
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発行日 | 2013-01
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出版物タイトル |
Oncology Reports
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巻 | 29巻
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号 | 1号
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開始ページ | 133
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終了ページ | 140
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ISSN | 1021-335X
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://dx.doi.org/10.3892/or.2012.2087
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/51970
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言語 |
英語
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
Web of Science KeyUT |