ID | 32623 |
JaLCDOI | |
フルテキストURL | |
著者 |
Furuno, Katsushi
Okayama University
Gomita, Yutaka
Okayama University
Oishi, Ryozo
Okayama University
Saeki, Kiyomi
Okayama University
Araki, Yasunori
Okayama University
|
抄録 | The plasma concentration of indomethacin was measured after the rectal administration of water-soluble and fatty base suppositories in rats. The results were compared with the in vitro indomethacin release from suppositories determined by Paddle method using three different types of membranes: cellulose membrane, artificial sausage membrane and natural sausage membrane. The plasma concentrations of indomethacin during the first 4h after the rectal administration were higher in rats that received water-soluble base suppositories than in those that received fatty base types. When either a cellulose membrane or an artificial sausage membrane of cow protein was used in the Paddle method, the amount of indomethacin released from fatty base suppositories was significantly higher than that from water-soluble base ones. However, the results were reversed when a natural sausage membrane of pig colon was used. The discrepancy in the in vitro experiments using water-soluble base suppositories seemed to be due to the difference of pore size of membrane used. Careful consideration should be given to the membrane used in the Paddle method especially when this method is employed to examine the release of poorly soluble drugs like indomethacin in both water-soluble and fatty base suppositories. |
キーワード | indomethacin
suppository
in vitro
cellulose membrane
sausage membrane
in vivo bioavailability
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1992-08
|
巻 | 46巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 223
|
終了ページ | 231
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |