ID | 32097 |
JaLCDOI | |
フルテキストURL | |
著者 |
Koirala, Tirtha Raj
Okayama University
Hayashi, Kazuhiko
Tottori University, Tottori
Jin, Zaishun
Okayama University
Onoda, Sachiyo
Okayama University
Tanaka, Takehiro
Okayama University
Oda, Wakako
Okayama University
Ohara, Nobuya
Okayama University
|
抄録 | Epstein-Barr virus (EBV)-related herpesvirus (Si-IIA-EBV) was serially transmitted for 3 passages from rabbit to rabbit of the opposite sex by blood transfusion, which subsequently induced virus-associated rabbit lymphomas. The virus could be transmitted by transfusion with 15-20 ml of whole blood (7/7) or irradiated blood (1/6) from the EBV-related virus-infected rabbits, but there was no transmission with transfusion of cell-free plasma (0/6) from the infected rabbits. Passive anti-EBV-VCA IgG (x 20 approximately x 10) titers decreased during the first 1-2 weeks in the transfused rabbits. The virus-transmitted rabbits showed a gradual increase in antibody titers ranging from peak titers of x 640 to x 2560 after 3 weeks of transfusion. The recipient origin of malignant lymphoma that developed in the first rabbit transfused by infected blood was confirmed by chromosomal analysis. This rabbit model thus shows that EBV-related herpesvirus is serially transmissible by blood transfusion and that transmission can not be completely prevented by irradiation of blood, but removal of blood cells is the best way to prevent transmission of EBV-related virus. Therefore, this animal model provides a convenient in vivo system for studies of the prevention and therapy of transfusion-related transmission of EBV and EBV-associated lymphoproliferative diseases in immunocompromised human beings. |
キーワード | ?Epstein-Barr virus(EBV)
rabbit
lymphoproliferative diseases
blood transfusion
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2004-04
|
巻 | 58巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
開始ページ | 67
|
終了ページ | 74
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |