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ID 61281
フルテキストURL
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著者
Han, Yanyan Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences ORCID
Igawa, Takuro Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Ogino, Kyohei Department of Pathology, Fukuyama City Hospital
Nishikori, Asami Division of Pathophysiology, Okayama University Graduate School of Health Sciences
Gion, Yuka Division of Pathophysiology, Okayama University Graduate School of Health Sciences Kaken ID researchmap
Yoshino, Tadashi Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Kaken ID publons researchmap
Sato, Yasuharu Division of Pathophysiology, Okayama University Graduate School of Health Sciences ORCID Kaken ID researchmap
抄録
Plasma cell-type Castleman disease (PCD) is a rare idiopathic atypical lymphoproliferative disorder. It is difficult to differentiate between PCD and IgG4-related disease (IgG4-RD) based on histology alone. As PCD often presents with abundant hemosiderin deposition, lymph node lesions obtained from 22 PCD patients and 12 IgG4-RD patients were analyzed using Prussian blue staining to clarify whether hemosiderin deposition is effective in distinguishing between these two diseases. The analysis disclosed that hemosiderin was more densely deposited in PCD than in IgG4-RD. The median number of Prussian blue-positive cells ± standard deviation (SD) in PCD and IgG4-RD cases was 13 ± 36 cells/3HPFs and 4 ± 8 cells/3HPFs (P = 0.034), respectively. In addition, we analyzed the relationship between hemosiderin deposition and levels of serum interleukin (IL)-6, serum C-reactive protein (CRP), and anemia-related biomarkers. We found that hemosiderin deposition was significantly correlated with the level of serum CRP (P = 0.045); however, no significant correlation was observed between hemosiderin deposition and serum IL-6 levels (P = 0.204). A non-significant positive correlation was observed between hemosiderin deposition and serum hemoglobin levels (P=0.09). Furthermore, no significant correlation was observed between hemosiderin deposition and serum iron levels (P = 0.799). In conclusion, hemosiderin deposition characteristically observed in PCD may be related to the inflammatory aggressiveness of the disease and could be used for its differential diagnosis.
キーワード
hemosiderin deposition
plasma cell-type Castleman disease
IgG4-related disease
serum IL-6
serum C-reactive protein
発行日
2020
出版物タイトル
Journal of Clinical and Experimental Hematopathology
60巻
1号
出版者
The Japanese Society for Lymphoreticular Tissue Research
開始ページ
1
終了ページ
6
ISSN
1346-4280
NCID
AA11556796
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2020 by The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン
publisher
PubMed ID
NAID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.3960/jslrt.19037
ライセンス
https://creativecommons.org/licenses/by-nc-sa/4.0/