ID | 61281 |
フルテキストURL | |
著者 |
Han, Yanyan
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
Igawa, Takuro
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Ogino, Kyohei
Department of Pathology, Fukuyama City Hospital
Nishikori, Asami
Division of Pathophysiology, Okayama University Graduate School of Health Sciences
Gion, Yuka
Division of Pathophysiology, Okayama University Graduate School of Health Sciences
Kaken ID
researchmap
Yoshino, Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Sato, Yasuharu
Division of Pathophysiology, Okayama University Graduate School of Health Sciences
ORCID
Kaken ID
researchmap
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抄録 | Plasma cell-type Castleman disease (PCD) is a rare idiopathic atypical lymphoproliferative disorder. It is difficult to differentiate between PCD and IgG4-related disease (IgG4-RD) based on histology alone. As PCD often presents with abundant hemosiderin deposition, lymph node lesions obtained from 22 PCD patients and 12 IgG4-RD patients were analyzed using Prussian blue staining to clarify whether hemosiderin deposition is effective in distinguishing between these two diseases. The analysis disclosed that hemosiderin was more densely deposited in PCD than in IgG4-RD. The median number of Prussian blue-positive cells ± standard deviation (SD) in PCD and IgG4-RD cases was 13 ± 36 cells/3HPFs and 4 ± 8 cells/3HPFs (P = 0.034), respectively. In addition, we analyzed the relationship between hemosiderin deposition and levels of serum interleukin (IL)-6, serum C-reactive protein (CRP), and anemia-related biomarkers. We found that hemosiderin deposition was significantly correlated with the level of serum CRP (P = 0.045); however, no significant correlation was observed between hemosiderin deposition and serum IL-6 levels (P = 0.204). A non-significant positive correlation was observed between hemosiderin deposition and serum hemoglobin levels (P=0.09). Furthermore, no significant correlation was observed between hemosiderin deposition and serum iron levels (P = 0.799). In conclusion, hemosiderin deposition characteristically observed in PCD may be related to the inflammatory aggressiveness of the disease and could be used for its differential diagnosis.
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キーワード | hemosiderin deposition
plasma cell-type Castleman disease
IgG4-related disease
serum IL-6
serum C-reactive protein
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発行日 | 2020
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出版物タイトル |
Journal of Clinical and Experimental Hematopathology
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巻 | 60巻
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号 | 1号
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出版者 | The Japanese Society for Lymphoreticular Tissue Research
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開始ページ | 1
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終了ページ | 6
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ISSN | 1346-4280
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NCID | AA11556796
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2020 by The Japanese Society for Lymphoreticular Tissue Research
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論文のバージョン | publisher
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PubMed ID | |
NAID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3960/jslrt.19037
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ライセンス | https://creativecommons.org/licenses/by-nc-sa/4.0/
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