ID | 48709 |
フルテキストURL | |
著者 |
Yamaoka, Kiyonori
Departments of Radiological Technology, Okayama University Medical School
Kaken ID
publons
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Mitsunobu, Fumihiro
Misasa Medical Center, Okayama University Medical School
Kaken ID
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Kojima, Shuji
Faculty of Pharmaceutical Sciences, Science University of Tokyo
Shibakura, Misako
Departments of Medical Technology, Okayama University Medical School
Kaken ID
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Kataoka, Takahiro
Departments of Radiological Technology, Okayama University Medical School
ORCID
Kaken ID
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Hanamoto, Katsumi
Departments of Radiological Technology, Okayama University Medical School
Kaken ID
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Tanizaki, Yoshiro
Misasa Medical Center, Okayama University Medical School
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抄録 | To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer-suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur.
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キーワード | Radon hot spring
Misasa
Cancer-related mortality rate
p53 protein level
Superoxide dismutase activity
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発行日 | 2005-04-01
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出版物タイトル |
Journal of Radiation Research
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巻 | 46巻
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号 | 1号
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出版者 | Journal of Radiation Research Editorial Committee
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開始ページ | 21
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終了ページ | 24
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ISSN | 0449-3060
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NCID | AA00705792
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/jrr/46/1/46_1_21/_article
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言語 |
英語
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著作権者 | Copyright © 2005 by Journal of Radiation Research Editorial Committee
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
PubMed ID | |
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