A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation

Cerebral cavernous malformations (CCMs) are congenital abnormalities of cerebral vessels. Surgical resection is rarely considered for the control of epilepsy in a first seizure patient with vascular malformation. In contrast, lesions that produce repetitive or progressive symptoms should be considered for surgical resection as treatment. Herein, we report a Japanese patient with a CCM2 mutation, c.609G>A (p.K203K) substitution, who showed drug-resistant epilepsy and dramatic improvement after surgical resection.

This is the peer reviewed version of the following article: [Nomura, E, Omote, Y, Takemoto, M, et al. A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation. Neurol Clin Neurosci. 2022; 10: 255- 258. doi: 10.1111/ncn3.12649], which has been published in final form at [https://doi.org/10.1111/ncn3.12649]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.