ID | 48712 |
フルテキストURL | |
著者 |
Nakagawa, Shinya
Graduate School of Health Sciences, Okayama University
Kataoka, Takahiro
Graduate School of Health Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
Mizuguchi, Yuko
Graduate School of Health Sciences, Okayama University
Yoshimoto, Masaaki
Graduate School of Health Sciences, Okayama University
Sakoda, Akihiro
Graduate School of Health Sciences, Okayama University
Nomura, Takaharu
Radiation Safety Research Center, Central Research Institute of Electric Power Industry
Wang, Da-Hong
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kaken ID
publons
researchmap
Yamaoka, Kiyonori
Graduate School of Health Sciences, Okayama University
Kaken ID
publons
researchmap
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抄録 | To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn’t significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.
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キーワード | acatalasemic mouse
radiosensitivity
catalase
glutathione peroxidase
total glutathione
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発行日 | 2008-07
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出版物タイトル |
Journal of Clinical Biochemistry and Nutrition
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巻 | 43巻
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号 | 1号
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出版者 | The Editorial Secretariat of JCBN
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開始ページ | 41
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終了ページ | 49
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ISSN | 0912-0009
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NCID | AA10710201
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/jcbn/43/1/43_2008042/_article
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/21480
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言語 |
英語
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著作権者 | Copyright © 2008 by The Editorial Secretariat of JCBN
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
Web of Science KeyUT |