ID | 61270 |
フルテキストURL | |
著者 |
Wang, Heng
School of Mechatronic Engineering, Beijing Institute of Technology
Shi, Zhongyan
School of Life Science, Beijing Institute of Technology
Sun, Weiqian
School of Life Science, Beijing Institute of Technology
Zhang, Jianxu
School of Mechatronic Engineering, Beijing Institute of Technology
Wang, Jing
Department of Health Management, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine
Shi, Yue
Beijing Big-IQ Medical Equipment Co., Ltd.
Yang, Ruoshui
School of Mechatronic Engineering, Beijing Institute of Technology
Li, Chunlin
School of Biomedical Engineering, Capital Medical University
Chen, Duanduan
School of Life Science, Beijing Institute of Technology
Wu, Jinglong
School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
ORCID
Kaken ID
publons
researchmap
Gongyao, Guo
School of Life Science, Beijing Institute of Technology
Xu, Yifei
School of Life Science, Beijing Institute of Technology
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抄録 | Methods by which to achieve non-invasive deep brain stimulation via temporally interfering with electric fields have been proposed, but the precision of the positioning of the stimulation and the reliability and stability of the outputs require improvement. In this study, a temporally interfering electrical stimulator was developed based on a neuromodulation technique using the interference modulation waveform produced by several high-frequency electrical stimuli to treat neurodegenerative diseases. The device and auxiliary software constitute a non-invasive neuromodulation system. The technical problems related to the multichannel high-precision output of the device were solved by an analog phase accumulator and a special driving circuit to reduce crosstalk. The function of measuring bioimpedance in real time was integrated into the stimulator to improve effectiveness. Finite element simulation and phantom measurements were performed to find the functional relations among the target coordinates, current ratio, and electrode position in the simplified model. Then, an appropriate approach was proposed to find electrode configurations for desired target locations in a detailed and realistic mouse model. A mouse validation experiment was carried out under the guidance of a simulation, and the reliability and positioning accuracy of temporally interfering electric stimulators were verified. Stimulator improvement and precision positioning solutions promise opportunities for further studies of temporally interfering electrical stimulation.
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キーワード | electrical stimulation
temporally interfering
finite element method
simulation
mouse
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発行日 | 2020-12-08
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出版物タイトル |
Frontiers in Neuroinformatics
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巻 | 14巻
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出版者 | Frontiers Media
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開始ページ | 574189
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ISSN | 1662-5196
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2020 Wang, Shi, Sun, Zhang,Wang, Shi, Yang, Li, Chen,Wu, Gongyao and Xu.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3389/fninf.2020.574189
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ライセンス | https://creativecommons.org/licenses/by/4.0/
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助成機関名 |
日本学術振興会
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助成番号 | 18K18835
18H01411
19KK0099
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