ID | 64274 |
フルテキストURL | |
著者 |
Nojima, Ichiro
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Wada, Jun
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
|
抄録 | Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D) and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are also recognized. Metformin modulates the differentiation and activation of various immune-mediated cells such as CD4+ and CD+8 T cells. The activation of adenosine 5 '-monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1) pathway may be involved in this process. Recent studies using Extracellular Flux Analyzer demonstrated that metformin alters the activities of glycolysis, oxidative phosphorylation (OXPHOS), lipid oxidation, and glutaminolysis, which tightly link to the modulation of cytokine production in CD4+ and CD+8 T cells in various disease states, such as virus infection, autoimmune diseases, aging and cancers.
|
キーワード | CD8 T cells
AMPK
mTORC
OXPHOS
autoimmune disease
aging
cancer
|
発行日 | 2023-01-01
|
出版物タイトル |
International Journal Of Molecular Sciences
|
巻 | 24巻
|
号 | 1号
|
出版者 | MDPI
|
開始ページ | 755
|
ISSN | 1422-0067
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © 2023 by the authors.
|
論文のバージョン | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/ijms24010755
|
ライセンス | https://creativecommons.org/licenses/by/4.0/
|
助成機関名 |
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development
|
助成番号 | 22H03088
22ek0109445h0003
|