ID | 61545 |
フルテキストURL | |
著者 |
Matsuo, Toshihiko
Okayama University Graduate School of Interdisciplinary Science and Engineering in Health Systems
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Tanaka, Takehiro
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Sato, Yasuharu
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Kataoka, Hitomi
Department of General Medicine, Okayama University Hospital
Uka, Mayu
Department of Radiology, Okayama University Hospital
Ennishi, Daisuke
Department of Hematology/Oncology, Okayama University Hospital
Yano, Tomofumi
Department of Internal Medicine, Okayama Rosai Hospital
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抄録 | The diagnostic criteria for IgG4-related disease were previously published and serum IgG4 measurement has been reimbursed by national health insurance in Japan since 2012. Eight patients diagnosed with IgG4-related disease based on lacrimal gland masses were retrospectively reviewed. The 8 patients were 3 men and 5 women ranging in age from 52 to 77 (median, 63) years at the initial visit and their follow-up period ranged from 0.25 to 11 (median, 7) years. Bilateral and unilateral involvement were noted in 4 patients each; 2 on the right side and 2 on the left side in those with unilateral involvement. Serum IgG4 was high in 5 of 8 patients at the initial visit. Five patients with no systemic signs were followed without treatment, whereas oral steroids were administered and tapered in the other 3 patients who exhibited systemic signs. One patient with a history of radiation for MALT lymphoma in bilateral lacrimal glands developed IgG4-related disease in the left lacrimal gland 10 years later and was followed without treatment. Nine years later, her serum IgG4 level increased to 1500 mg/dL and paracardiac lesions, found on positron emission tomography, were confirmed to be MALT lymphoma by needle biopsy, leading to systemic chemotherapy. The other 7 patients had neither local recurrence nor additional systemic signs. Serum IgG4 monitoring may be useful to detect systemic complications in IgG4-related ophthalmic disease and markedly high serum IgG4 levels may indicate new lymphoma at other sites.
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キーワード | IgG4-related disease
lacrimal gland
serum IgG4
prednisolone
extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
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発行日 | 2021
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出版物タイトル |
Journal of Clinical and Experimental Hematopathology
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巻 | 61巻
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号 | 1号
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出版者 | Japanese Society for Lymphoreticular Tissue Research
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開始ページ | 10
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終了ページ | 20
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ISSN | 1346-4280
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NCID | AA11556796
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2021 by The Japanese Society for Lymphoreticular Tissue Research
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
関連URL | isVersionOf https://doi.org/10.3960/jslrt.20048
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ライセンス | https://creativecommons.org/licenses/by-nc-sa/4.0/
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