フルテキストURL fulltext.pdf
著者 Ihara, Hiroki| Yoshio, Kotaro| Tanabe, Shunsuke| Sugiyama, Soichi| Hashimoto, Masashi| Maeda, Naoaki| Akagi, Shinsuke| Takao, Soshi| Noma, Kazuhiro| Hiraki, Takao|
キーワード Radiation therapy Esophageal squamous cell carcinoma Recurrence 18F-fluorodeoxyglucose positron emission tomography Survival
備考 The version of record of this article, first published in Esophagus, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10388-023-01000-4|
発行日 2023-04-07
出版物タイトル Esophagus
20巻
3号
出版者 Springer Science and Business Media LLC
開始ページ 548
終了ページ 556
ISSN 1612-9059
NCID AA11885266
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2023
論文のバージョン publisher
PubMed ID 37027045
DOI 10.1007/s10388-023-01000-4
Web of Science KeyUT 000964113700001
関連URL isVersionOf https://doi.org/10.1007/s10388-023-01000-4
フルテキストURL fulltext.pdf
著者 Matsumoto, Naomi| Sasaki, Ayako| Kadowaki, Tomoka| Mitsuhashi, Toshiharu| Takao, Soshi| Yorifuji, Takashi|
備考 The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-55245-9|
発行日 2024-02-25
出版物タイトル Scientific Reports
14巻
1号
出版者 Nature Portfolio
開始ページ 4564
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2024
論文のバージョン publisher
PubMed ID 38403650
DOI 10.1038/s41598-024-55245-9
Web of Science KeyUT 001177180300006
関連URL isVersionOf https://doi.org/10.1038/s41598-024-55245-9
JaLCDOI 10.18926/AMO/66672
フルテキストURL 78_1_063.pdf
著者 Murakami, Daizo| Nishimoto, Kohei| Takao, Soshi| Miyamaru, Satoru| Kadowaki, Tomoka| Saito, Haruki| Takeda, Hiroki| Ise, Momoko| Suyama, Koichi| Orita, Yorihisa|
抄録 The tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated with a <8 mg/day mean dose of lenvatinib was significantly better than that of the patients treated with 8-24 mg/day (hazard ratio [HR] 0.38 for 1.14-4.54 mg/day, and HR 0.01 for 4.56-7.97 mg/day) adjusted for various factors (e.g., sex, age, drug interruption period). The cumulative dose of lenvatinib administered tended to be higher in the patients treated with low doses (< 8 mg/day) than in the patients treated with relatively high doses (8-24 mg/day). Considering its adverse events, the continuation of lenvatinib treatment with an adequate daily dose and drug interruption may help prolong the survival of patients with unresectable thyroid carcinoma.
キーワード thyroid carcinoma lenvatinib adverse effect survival
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 63
終了ページ 70
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419316
JaLCDOI 10.18926/AMO/66668
フルテキストURL 78_1_029.pdf
著者 Kitayama, Takahiro| Tanaka, Takashi| Kanie, Yuichiro| Marukawa, Yohei| Kojima, Katsuhide| Tanaka, Takehiro| Takao, Soshi| Hiraki, Takao|
抄録 This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD.
キーワード methotrexate lymphoproliferative disorder computed tomography necrosis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 29
終了ページ 36
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38419312
JaLCDOI 10.18926/AMO/66152
フルテキストURL 77_6_607.pdf
著者 Tani, Yasunari| Kashima, Saori| Mitsuhashi, Toshiharu| Suzuki, Etsuji| Takao, Soshi| Yorifuji, Takashi|
抄録 Many studies have shown an association between long-term exposure to particulate matter having an aerodynamic diameter of 2.5 μm or less (PM2.5) and diabetes mellitus (DM), but few studies have focused on Asian subjects. We thus examined the association between long-term exposure to PM2.5 and DM prevalence in Okayama City, Japan. We included 76,591 participants who had received basic health checkups in 2006 and 2007. We assigned the census-level modeled PM2.5 data from 2006 and 2007 to each participant and defined DM using treatment status and the blood testing. PM2.5 was associated with DM prevalence, and the prevalence ratio (95% confidence interval) was 1.10 (1.00-1.20) following each interquartile range increase (2.1 μg/m3) in PM2.5. This finding is consistent with previous results and suggests that long-term exposure to PM2.5 is associated with an increased prevalence of DM in Okayama City, Japan, where the PM2.5 level is lower than in other cities in Asian countries.
キーワード air pollution diabetes mellitus epidemiology glycosylated hemoglobin particulate matter
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-12
77巻
6号
出版者 Okayama University Medical School
開始ページ 607
終了ページ 612
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38145934
Web of Science KeyUT 001164631200005
JaLCDOI 10.18926/AMO/66148
フルテキストURL 77_6_567.pdf
著者 Matsumoto, Naomi| Higuchi, Chigusa| Miyaji, Chikara| Mitsuhashi, Toshiharu| Hagiya, Hideharu| Takao, Soshi| Yorifuji, Takashi|
抄録 This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic.
キーワード coronavirus disease 2019 adverse reactions mRNA vaccine antibody titers young adults
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2023-12
77巻
6号
出版者 Okayama University Medical School
開始ページ 567
終了ページ 575
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38145930
Web of Science KeyUT 001164631200001
JaLCDOI 10.18926/AMO/65971
フルテキストURL 77_5_491.pdf
著者 Habu, Hiroshi| Takao, Soshi| Miyaji, Chikara| Matsumoto, Naomi| Aoo, Ken| Nishita, Yosuke| Tsuri, Masao| Yorifuji, Takashi|
抄録 Arts festivals have become increasingly popular in various parts of Japan in recent years. The purpose of this study was to investigate the relationships between arts festival activities participation at the Setouchi Triennale and the health of residents in the town of Naoshima. This was a cross-sectional study. Questionnaires were distributed to all residents of Naoshima who were 20 years old or older (n=2,588). We analyzed responses from 708 people. The associations between arts festival activities participation and health (measured by self-rated health) were analyzed using logistic regression analysis as the primary outcome. Kessler’s psychological distress scale scores were also analyzed in the same manner as the primary outcome. The participating group had an adjusted odds ratio of 1.86 (95% confidence interval: 1.03-3.33) for higher self-rated health compared with those who did not participate. Kessler’s psychological distress scale results showed that the participating group had an adjusted odds ratio of 3.23 (95% confidence interval: 1.19-8.81) for lower psychological distress compared with those who did not participate. In conclusion, arts festival activities participation was associated with higher self-rated health and lower psychological distress. However, caution must be taken in regard to generalizability and causality when interpreting these results.
キーワード art arts in public health arts festival self-rated health Setouchi Triennale
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-10
77巻
5号
出版者 Okayama University Medical School
開始ページ 491
終了ページ 497
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37899260
Web of Science KeyUT 001108661600006
JaLCDOI 10.18926/AMO/65970
フルテキストURL 77_5_479.pdf
著者 Murata, Akiko| Matsumoto, Naomi| Miyaji, Chikara| Takao, Soshi| Yorifuji, Takashi|
抄録 For decades, the notion has persisted in developed countries that exclusive care by the mothers is best for the development of children up to 3 years of age. To examine the veracity of this “myth of the first three years” in Japan, we examined the effects of childcare facility use for children younger than 3 years on their development using the cohorts of the Longitudinal Survey of Newborns in the 21st Century conducted in Japan. Of the 47,015 respondents to the survey, we studied the children of 5,508 mothers with university/professional education to evaluate the relationships between primary early (< 2.5 years) childcare providers during weekday daytime hours and specific development indices for the ages of 2.5, 5.5, and 8 years. At the age of 2.5 and 5.5 years, children attending childcare facilities were judged as having more advanced developmental behaviors by their parents, such as being able to compose a two-word sentence (adjusted odds ratio [aOR]: 0.22) or to express emotions (aOR: 0.81), compared with those cared for by mothers. However, at the age of 8 years, children who attended childcare facilities as infants < 2.5 years showed more aggressive behavior in interrupting people (aOR: 1.20) and causing disturbances in public (aOR: 1.26) than those cared for by mothers (after adjustment for numerous child and parental factors). Although these results are generally consistent with previous studies, issues potentially involved with problem behavior such as quality of childcare require further investigation, as does the case of children of mothers with more modest educational attainment.
キーワード “myth of the first three years” childcare child development problem behavior educational attainment
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-10
77巻
5号
出版者 Okayama University Medical School
開始ページ 479
終了ページ 490
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37899259
Web of Science KeyUT 001108661600005
JaLCDOI 10.18926/AMO/65966
フルテキストURL 77_5_443.pdf
著者 Miyaji, Chikara| Takao, Soshi| Habu, Hiroshi| Matsumoto, Naomi| Aoo, Ken| Nishita, Yosuke| Tsuri, Masao| Yorifuji, Takashi|
抄録 This study examined whether participation in an art project was associated with higher social capital (SC). We conducted a questionnaire survey from November 2021 to March 2022 among residents aged 20 years or older of Naoshima, an island in Kagawa Prefecture, Japan. Before the survey, the Setouchi Triennale had been held on Naoshima four times, starting in 2010. We calculated propensity scores for Triennale participation and performed propensity score matching. We then compared cognitive and structural SC by Triennale participation and found significant differences, respectively. We adopted a conditional ordered logistic regression analysis with propensity score matching for cognitive or structural SC, and found adjusted odd ratios of 2.913 (95%CI, 1.846-4.596) for cognitive SC and 4.535 (95%CI, 2.839-7.244) for structural SC. Our findings suggest that Triennale participation enhanced the cognitive aspect of SC while also building structural SC.
キーワード social capital art project propensity score matching
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-10
77巻
5号
出版者 Okayama University Medical School
開始ページ 443
終了ページ 449
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37899255
Web of Science KeyUT 001108661600001
フルテキストURL fulltext20231013-02.pdf
著者 Matsumoto, Naomi| Kadowaki, Tomoka| Matsuo, Rumi| Sasaki, Ayako| Miyaji, Chikara| Higuchi, Chigusa| Nakayama, Masanori| Sakurada, Yasue| Hagiya, Hideharu| Takao, Soshi| Otsuka, Fumio| Yorifuji, Takashi|
キーワード SARS-CoV-2 mRNA-1273 antibody reactogenicity adverse reaction
発行日 2022-12-05
出版物タイトル Journal of Epidemiology
32巻
12号
出版者 Japan Epidemiological Association
開始ページ 567
終了ページ 569
ISSN 0917-5040
NCID AA10952696
資料タイプ 一般雑誌記事
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Naomi Matsumoto et al.
論文のバージョン publisher
PubMed ID 36031363
DOI 10.2188/jea.je20220210
Web of Science KeyUT 000884682100001
関連URL isVersionOf https://doi.org/10.2188/jea.JE20220210
JaLCDOI 10.18926/AMO/65749
フルテキストURL 77_4_387.pdf
著者 Kataoka, Takahiro| Habu, Hiroshi| Tanaka, Ayumi| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Takao, Soshi| Mitsunobu, Fumihiro| Yorifuji, Takashi| Yamaoka, Kiyonori|
抄録 No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis.
キーワード radon hot spring bathing habit self-rated health cross-section study
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 387
終了ページ 394
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635139
Web of Science KeyUT 001163659800003
タイトル(別表記) Clusters of coronavirus disease 2019 in medical institutions and elderly care facilities in Okayama Prefecture
著者 門脇 知花| 入江 佐織| 髙橋 友香里| 薬師寺 泰匡| 高尾 総司| 賴藤 貴志|
抄録  Coronavirus disease 2019 has spread worldwide and has yet to be contained. The Japanese government has taken measures against the occurrence of clusters. However, there has little evaluation of the occurrence of the clusters and their changes. Therefore, we investigated the occurrence of the clusters in medical institutions and elderly care facilities in Okayama Prefecture.
 We compared the characteristics of the clusters that occurred in each of the wave between October 21, 2020, and September 30, 2021, by using the data published that interval. As a case study, we also evaluated the characteristics of positive patients at a medical institution over where a cluster occurred in case the fourth wave.
 The overall number of cluster outbreaks decreased with the spread of vaccination. In the fourth wave, there was a period in which the vaccination of staff members at medical institutions became widespread, while patients or facility users were unvaccinated, resulting in a longer convergence period and an increase in the number of positive cases among patients relative to the number of staff members.
 The impact of the spread of vaccination and the duration of immunity acquired after vaccination on the occurrence of clusters should be closely monitored in the future.
キーワード 新型コロナウイルス感染症(coronavirus disease 2019) 岡山県(Okayama Prefecture) クラスター(cluster) ワクチン接種(vaccination) 疫学(epidemiology)
出版物タイトル 岡山医学会雑誌
発行日 2022-08-01
134巻
2号
開始ページ 86
終了ページ 91
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.134.86
言語 日本語
著作権者 Copyright (c) 2022 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.134.86
フルテキストURL 12_setouchi_project_en.pdf
著者 Yorifuji, Takashi| Habu, Hiroshi| Miyaji, Chikara| Matsumoto, Naomi| Takao, Soshi|
発行日 2023-03
出版物タイトル Setouchi Sustainability and Well-being Research Project Final Report
資料タイプ 研究報告書
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
フルテキストURL 6_setouchi_project_ja.pdf
著者 賴藤 貴志| 土生 裕| 宮道 力| 松本 尚美| 高尾 総司|
発行日 2023-03
出版物タイトル 瀬戸内サステナビリティ&ウェルビーイング研究プロジェクト最終報告書
資料タイプ 研究報告書
言語 日本語
OAI-PMH Set 岡山大学
論文のバージョン publisher
タイトル(別表記) Report on adverse reactions to novel coronavirus vaccines
著者 松本 尚美| 樋口 千草| 三橋 利晴| 萩谷 英大| 高尾 総司| 賴藤 貴志|
キーワード COVID-19 m-RNA ワクチン 副反応 BNT162b mRNA-1273
出版物タイトル 岡山医学会雑誌
発行日 2022-04-01
134巻
1号
開始ページ 35
終了ページ 42
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.134.35
言語 日本語
著作権者 Copyright (c) 2022 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.134.35
フルテキストURL fulltext.pdf
著者 Habu, Hiroshi| Takao, Soshi| Fujimoto, Ryohei| Naito, Hiromichi| Nakao, Atsunori| Yorifuji, Takashi|
キーワード COVID-19 epidemiology emergency medical dispatch suicide
発行日 2021-07-17
出版物タイトル Journal of Epidemiology
31巻
9号
出版者 Japan Epidemiological Assoc.
開始ページ 511
終了ページ 517
ISSN 0917-5040
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 Hiroshi Habu et al.
論文のバージョン publisher
PubMed ID 34176855
DOI 10.2188/jea.JE20210066
Web of Science KeyUT 000680719500003
関連URL isVersionOf https://doi.org/10.2188/jea.JE20210066
フルテキストURL fulltext.pdf
著者 Oka, Aiko| Ninomiya, Takahiro| Fujiwara, Tazuko| Takao, Soshi| Sato, Yasuharu| Gion, Yuka| Minoura, Akira| Haruna, Shin-ichi| Yoshida, Naohiro| Sakuma, Yasunori| Izuhara, Kenji| Ono, Junya| Taniguchi, Masami| Haruna, Takenori| Higaki, Takaya| Kariya, Shin| Koyama, Takahisa| Takabayashi, Tetsuji| Imoto, Yoshimasa| Sakashita, Masafumi| Kidoguchi, Masanori| Nishizaki, Kazunori| Fujieda, Shigeharu| Okano, Mitsuhiro|
キーワード Chronic rhinosinusitis Eosinophils Eosinophils IgG4 Severity Surgery
発行日 2020-01-14
出版物タイトル Allergology International
出版者 Elsevier
ISSN 13238930
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.
論文のバージョン publisher
PubMed ID 31952913
DOI 10.1016/j.alit.2019.12.004
関連URL isVersionOf https://doi.org/10.1016/j.alit.2019.12.004
著者 Kobayashi, Tomoko| Suzuki, Etsuji| Oksanen, Tuula| Kawachi, Ichiro| Takao, Soshi|
発行日 2014-01-31
出版物タイトル PLoS ONE
9巻
1号
資料タイプ 学術雑誌論文
著者 Kishimoto, Yoko| Suzuki, Etsuji| Iwase, Toshihide| Doi, Hiroyuki| Takao, Soshi|
発行日 2013-12-17
出版物タイトル BMC Public Health
13巻
資料タイプ 学術雑誌論文
著者 Kasai, Yosuke| Suzuki, Etsuji| Iwase, Toshihide| Doi, Hiroyuki| Takao, Soshi|
発行日 2013-10-17
出版物タイトル PLoS ONE
8巻
10号
資料タイプ 学術雑誌論文