| JaLCDOI |
10.18926/AMO/64363
|
| フルテキストURL |
77_1_65.pdf
|
| 著者 |
Sato, Ken|
Takigawa, Nagio|
Kubo, Toshio|
Katayama, Hideki|
Kishino, Daizo|
Okada, Toshiaki|
Hisamoto, Akiko|
Mimoto, Junko|
Ochi, Nobuaki|
Yoshino, Tadashi|
Ueoka, Hiroshi|
Tanimoto, Mitsune|
Maeda, Yoshionobu|
Kiura, Katsuyuki|
|
| 抄録 |
We investigated the effects of celecoxib combined with (−)-epigallocatechin-3-gallate (EGCG) or polyphenon E in a cisplatin-induced lung tumorigenesis model. Four-week-old female A/J mice were divided into seven groups: (i) Control, (ii) 150 mg/kg celecoxib (150Cel), (iii) 1,500 mg/kg celecoxib (1500Cel), (iv) EGCG+150 mg/kg celecoxib (EGCG+150Cel), (v) EGCG+1,500 mg/kg celecoxib (EGCG+1500Cel), (vi) polyphenon E+150 mg/kg celecoxib (PolyE+150Cel), and (vii) polyphenon E+1,500 mg/kg celecoxib (PolyE+1500Cel). All mice were administered cisplatin (1.62 mg/kg of body weight, i.p.) 1×/week for 10 weeks and sacrificed at week 30; the numbers of tumors on the lung surface were then determined. The tumor incidence and multiplicity (no. of tumors/mouse, mean±SD) were respectively 95% and 2.15±1.50 in Control, 95% and 2.10±1.29 in 150Cel, 86% and 1.67±1.20 in 1500Cel, 71% and 1.38±1.24 in EGCG+150Cel, 67% and 1.29±1.38 in EGCG+1500Cel, 80% and 1.95±1.36 in PolyE+150Cel, and 65% and 1.05±0.10 in PolyE+1500Cel. The combination of high-dose celecoxib with EGCG or polyphenon E significantly reduced multiplicity in cisplatin-induced lung tumors.
|
| キーワード |
celecoxib
cisplatin
EGCG
lung tumor
polyphenon E
|
| Amo Type |
Original Article
|
| 出版物タイトル |
Acta Medica Okayama
|
| 発行日 |
2023-02
|
| 巻 |
77巻
|
| 号 |
1号
|
| 出版者 |
Okayama University Medical School
|
| 開始ページ |
65
|
| 終了ページ |
70
|
| ISSN |
0386-300X
|
| NCID |
AA00508441
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
英語
|
| 著作権者 |
Copyright Ⓒ 2023 by Okayama University Medical School
|
| 論文のバージョン |
publisher
|
| 査読 |
有り
|
| PubMed ID |
36849147
|
| Web of Science KeyUT |
000952992100004
|
