ID | 50624 |
フルテキストURL | |
著者 |
Inoue, Junko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Wada, Jun
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
ORCID
Kaken ID
publons
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Teshigawara, Sanae
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Kaken ID
Hida, Kazuyuki
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Nakatsuka, Atsuko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Kaken ID
publons
researchmap
Takatori, Yuji
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Kojo, Shoichirou
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Akagi, Shigeru
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Nakao, Kazushi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Miyatake, Nobuyuki
Kagawa Univ, Fac Med, Dept Hyg
McDonald, John F.
Millipore Corp, Linco Res
Makino, Hirofumi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
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抄録 | Background: Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans. Recently, we found that 7% of the Japanese population with the minor allele sequence (A) of rs77060950 exhibit higher levels of serum vaspin. We therefore evaluated the serum vaspin levels in Japanese chronic hemodialysis patients.
Methods: Healthy Japanese control volunteers (control; n = 95, 49.9 +/- 6.91 years) and Japanese patients undergoing hemodialysis therapy (HD; n = 138, 51.4 +/- 10.5 years) were enrolled in this study, and serum samples were subjected to the human vaspin RIA system.
Results: The measurement of the serum vaspin levels demonstrated that a fraction of control subjects (n = 5) and HD patients (n = 11) exhibited much higher levels (> 10 ng/ml; Vaspin(High) group), while the rest of the population exhibited lower levels (< 3 ng/ml; Vaspin(Low) group). By comparing the patients in the Vaspin(Low) group, the serum vaspin levels were found to be significantly higher in the control subjects (0.87 +/- 0.24 ng/ml) than in the HD patients (0.32 +/- 0.15 ng/ml) (p < 0.0001). In the stepwise regression analyses, the serum creatinine and triglyceride levels were found to be independently and significantly associated with the vaspin concentrations in all subjects.
Conclusions: The creatinine levels are negatively correlated with the serum vaspin levels and were significantly reduced in the Japanese HD patients in the Vaspin(Low) group.
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キーワード | Adipokine
End-stage renal disease
Hemodialysis
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発行日 | 2012-12-03
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出版物タイトル |
BMC Nephrology
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巻 | 13巻
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出版者 | Biomed Central Ltd
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ISSN | 1471-2369
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://dx.doi.org/10.1186/1471-2369-13-163
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50624
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言語 |
英語
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
Web of Science KeyUT |