ID | 49110 |
フルテキストURL | |
著者 |
Takahashi, Kanayo
Okayama Univ Hosp
Murayama, Yumeno
Okayama Univ Hosp
Udagawa, Mika
Okayama Univ Hosp
Nishimoto, Hitomi
Okayama Univ Hosp
Sugiura, Yuko
Okayama Univ Hosp
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抄録 | Severe oral mucositis induced by allogeneic hematopoietic cell transplantation (HCT) is associated with intolerable pain and risk of systemic bacteremia infection. Differences between conventional HCT and reduced-intensity regimens for allogeneic HCT (RIST) may influence the occurrence and severity of oral mucositis. Here, we evaluated oral mucositis in patients undergoing RIST and compared the results with those in conventional allogeneic HCT patients to facilitate predictive measures for mucositis.
A total of 127 consecutive patients undergoing HCT (conventional, 63; RIST, 64) were included in this study. Severity of oral mucositis during HCT period was evaluated daily. Differences in severity of mucositis among HCT types were analyzed. Use of morphine to control pain due to oral mucositis was evaluated in each HCT method.
The severity of oral mucositis was reduced in patients undergoing RIST. Worsening of oral mucositis was delayed in patients receiving RIST. Use of morphine to control pain due to oral mucositis was significantly decreased in patients undergoing RIST compared with those receiving conventional allogeneic HCT.
The severity of oral mucositis was reduced and the peak day of oral mucositis was delayed in RIST patients compared with those receiving conventional HCT.
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キーワード | Hematopoietic cell transplantation
Oral mucositis
Reduced-intensity regimens
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発行日 | 2010-01
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出版物タイトル |
Supportive Care in Cancer
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巻 | 18巻
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号 | 1号
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開始ページ | 115
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終了ページ | 119
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ISSN | 0941-4355
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://dx.doi.org/ 10.1007/s00520-009-0637-z
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言語 |
英語
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論文のバージョン | author
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査読 |
有り
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DOI | |
PubMed ID | |
Web of Science KeyUT |