ID | 65964 |
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著者 |
Okawa, Yukari
Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Suzuki, Etsuji
Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Mitsuhashi, Toshiharu
Center for Innovative Clinical Medicine, Okayama University Hospital
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Tsuda, Toshihide
Department of Human Ecology, Graduate School of Environmental and Life Science, Okayama University
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Yorifuji, Takashi
Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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抄録 | Chronic kidney disease (CKD) is a major global public health problem. Recent studies reported that diabetes and prediabetes are risk factors for developing CKD; however, the exact glycated hemoglobin (HbA1c) cut-off value for prediabetes remains controversial. In this study, we aimed to examine the relationship between HbA1c levels and subsequent CKD development in greater detail than previous studies. Longitudinal data of annual checkups of 7176 Japanese non-diabetic people (male: 40.4%) from 1998 to 2022 was analyzed. HbA1c values were categorized into < 5.0%, 5.0-5.4%, 5.5-5.9%, and 6.0-6.4%. CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m(2). The descriptive statistics at study entry showed that higher HbA1c values were associated with male, older, overweight or obese, hypertensive, or dyslipidemic people. During a mean follow-up of 7.75 person-years, 2374 participants (male: 40.0%) developed CKD. The Weibull accelerated failure time model was selected because the proportional hazards assumption was violated. The adjusted time ratios of developing CKD for HbA1c levels of 5.5-5.9% and 6.0-6.4% compared with 5.0-5.4% were 0.97 (95% confidence interval: 0.92-1.03) and 1.01 (95% confidence interval: 0.90-1.13), respectively. There was no association between HbA1c in the prediabetic range and subsequent CKD development.
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備考 | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-40300-8
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発行日 | 2023-08-23
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出版物タイトル |
Scientific Reports
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巻 | 13巻
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号 | 1号
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出版者 | Nature Portfolio
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開始ページ | 13770
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ISSN | 2045-2322
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © The Author(s) 2023
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論文のバージョン | publisher
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DOI | |
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関連URL | isVersionOf https://doi.org/10.1038/s41598-023-40300-8
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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Citation | Okawa, Y., Suzuki, E., Mitsuhashi, T. et al. A population-based longitudinal study on glycated hemoglobin levels and new-onset chronic kidney disease among non-diabetic Japanese adults. Sci Rep 13, 13770 (2023). https://doi.org/10.1038/s41598-023-40300-8
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助成機関名 |
Zentsuji city
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助成番号 | 7401700067
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