ID | 30325 |
JaLCDOI | |
フルテキストURL | |
著者 |
Tanizaki, Yoshiro
Okayama University
Komagoe, Haruki
Okayama University
Sudo, Michiyasu
Okayama University
Morinaga, Hiroshi
Okayama University
Kitani, Hikaru
Okayama University
Tada, Shinya
Okayama University
Takahashi, Kiyoshi
Okayama University
Kimura, Ikuro
Okayama University
|
抄録 | The correlation between blood eosinophilia and anti-IgE-mediated histamine release was investigated in 22 bronchial asthma patients with peripheral eosinophilia (over 8%). In the cases (Group A-1 and Group A-2) in which house dust was the specific antigen, significant histamine release from basophils was induced by anti-IgE and house dust. The result indicates a relationship between eosinophilia and the IgE-mediated mechanism of disease onset. In the cases (Group A-3) with RAST scores of 0+ and 1+ to house dust, the anti-IgE-induced histamine release varied from low to high percentages, and the participation of the IgE-mediated pathway was indicated in some cases. In the cases (Group B) with negative skin reactions, few patients had a family history of allergic disease. Their ages at onset were higher, and they demonstrated lower total IgE levels. These cases showed an extremely low percent of histamine release from basophils, which indicated the absence of a correlation between eosinophilia and IgE-mediated mechanisms. |
キーワード | blood eosinophilia
histamine release
IgE-mediated reaction
asthma
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1984-12
|
巻 | 38巻
|
号 | 6号
|
出版者 | Okayama University Medical School
|
開始ページ | 525
|
終了ページ | 531
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |