平成人

Safety and Efficacy of a Well-Fitting Brassiere after Breast Reconstruction: A Qualitative Study

JaLCDOI	10.18926/AMO/64356
フルテキストURL	77_1_11.pdf
著者	Watanabe, Satoko\| Saiga, Miho\| Motoki, Takayuki\| Shien, Tadahiko\| Taira, Naruto\| Doihara, Hiroyoshi\| Kimata, Yoshihiro\|
抄録	The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction.
キーワード	breast reconstruction mastectomy brassiere professional bra fitter
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-02
巻	77巻
号	1号
出版者	Okayama University Medical School
開始ページ	11
終了ページ	19
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36849141
Web of Science KeyUT	000953663800002

YES1 as a Therapeutic Target for HER2-Positive Breast Cancer after Trastuzumab and Trastuzumab-Emtansine (T-DM1) Resistance Development

フルテキストURL	fulltext.pdf
著者	Fujihara, Miwa\| Shien, Tadahiko\| Shien, Kazuhiko\| Suzawa, Ken\| Takeda, Tatsuaki\| Zhu, Yidan\| Mamori, Tomoka\| Otani, Yusuke\| Yoshioka, Ryo\| Uno, Maya\| Suzuki, Yoko\| Abe, Yuko\| Hatono, Minami\| Tsukioki, Takahiro\| Takahashi, Yuko\| Kochi, Mariko\| Iwamoto, Takayuki\| Taira, Naruto\| Doihara, Hiroyoshi\| Toyooka, Shinichi\|
キーワード	breast cancer YES1 T-DM1 dasatinib drug resistance
発行日	2021-11-26
出版物タイトル	International Journal Of Molecular Sciences
巻	22巻
号	23号
出版者	MDPI
開始ページ	12809
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34884609
DOI	10.3390/ijms222312809
Web of Science KeyUT	000735641400001
関連URL	isVersionOf https://doi.org/10.3390/ijms222312809

Prospective cohort study of febrile neutropenia in breast cancer patients administered with neoadjuvant and adjuvant chemotherapies: CSPOR-BC FN study

フルテキストURL	fulltext20210527_4.pdf
著者	Ishikawa, Takashi\| Sakamaki, Kentaro\| Narui, Kazutaka\| Nishimura, Hideki\| Sangai, Takafumi\| Tamaki, Kentaro\| Hasegawa, Yoshie\| Watanabe, Ken-ichi\| Suganuma, Nobuyasu\| Michishita, Shintaro\| Sugae, Sadatoshi\| Aihara, Tomohiko\| Tsugawa, Koichiro\| Kaise, Hirose\| Taira, Naruto\| Mukai, Hirofumi\|
キーワード	Breast cancer Febrile neutropenia Adjuvant chemotherapy Risk factors Prospective study
発行日	2021-04-30
出版物タイトル	The Breast
巻	56巻
出版者	Elsevier
開始ページ	70
終了ページ	77
ISSN	09609776
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Author(s).
論文のバージョン	publisher
PubMed ID	33631458
DOI	10.1016/j.breast.2021.01.005
Web of Science KeyUT	000632058800010
関連URL	isVersionOf https://doi.org/10.1016/j.breast.2021.01.005

Randomized phase II study to determine the optimal dose of 3-week cycle nab-paclitaxel in patients with metastatic breast cancer

フルテキストURL	fulltext.pdf
著者	Tsurutani, Junji\| Hara, Fumikata\| Kitada, Masahiro\| Takahashi, Masato\| Kikawa, Yuichiro\| Kato, Hiroaki\| Sakata, Eiko\| Naito, Yoichi\| Hasegawa, Yoshie\| Saito, Tsuyoshi\| Iwasa, Tsutomu\| Taira, Naruto\| Takashima, Tsutomu\| Kashiwabara, Kosuke\| Aihara, Tomohiko\| Mukai, Hirofumi\|
キーワード	Nab-paclitaxel Nanoparticle albumin–bound paclitaxel Metastatic breast cancer Solvent-base paclitaxel Chemotherapy-induced peripheral neuropathy
発行日	2020-12-09
出版物タイトル	The Breast
巻	55巻
出版者	Elsevier
開始ページ	63
終了ページ	68
ISSN	0960-9776
NCID	AA10844161
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
DOI	10.1016/j.breast.2020.12.002
関連URL	isVersionOf https://doi.org/10.1016/j.breast.2020.12.002

Evaluation of Prognosis of Juvenile Differentiated Thyroid Carcinoma

JaLCDOI	10.18926/AMO/60799
フルテキストURL	74_5_401.pdf
著者	Tsukioki, Takahiro\| Shien, Tadahiko\| Ohtani, Yusuke\| Fujihara, Miwa\| Suzuki, Yoko\| Kajihara, Yukiko\| Hatono, Minami\| Kawada, Kengo\| Kochi, Mariko\| Iwamoto, Takayuki\| Ikeda, Hirokuni\| Taira, Naruto\| Doihara, Hiroyoshi\|
抄録	Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC.
キーワード	differentiated thyroid carcinoma juvenile children
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-10
巻	74巻
号	5号
出版者	Okayama University Medical School
開始ページ	401
終了ページ	406
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33106695
Web of Science KeyUT	000581970100004
NAID	120006892925

Influences of preoperative metformin on immunological factors in early breast cancer

フルテキストURL	CCP_fulltext.pdf
著者	Tsukioki, Takahiro\| Shien, Tadahiko\| Tanaka, Takehiro\| Suzuki, Yoko\| Kajihara, Yukiko\| Hatono, Minami\| Kawada, Kengo\| Kochi, Mariko\| Iwamoto, Takayuki\| Ikeda, Hirokuni\| Taira, Naruto\| Doihara, Hiroyoshi\| Toyooka, Shinichi\|
キーワード	Breast cancer Metformin Preoperative Tils CD8 PD-L1
発行日	2020-06-12
出版物タイトル	Cancer Chemotherapy and Pharmacology
巻	86巻 86巻
号	1号 1号
出版者	Springer
開始ページ	55 55
終了ページ	63 63
ISSN	0344-5704
NCID	AA00598397
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©Author(s)
論文のバージョン	publisher
PubMed ID	32533334
DOI	10.1007/s00280-020-04092-2
Web of Science KeyUT	000539841500002
関連URL	isVersionOf https://doi.org/10.1007/s00280-020-04092-2

Recurring radiation-induced angiosarcoma of the breast that was treated with paclitaxel chemotherapy: a case report

フルテキストURL	fulltext.pdf
著者	Suzuki, Yoko\| Taniguchi, Kohei\| Hatono, Minami\| Kajiwara, Yukiko\| Abe, Yuko\| Kawada, Kengo\| Tsukioki, Takahiro\| Kochi, Mariko\| Nishiyama, Keiko\| Iwamoto, Takayuki\| Ikeda, Hirokuni\| Shien, Tadahiko\| Taira, Naruto\| Tabata, Masahiro\| Yanai, Hiroyuki\| Doihara, Hiroyoshi\|
キーワード	Radiation-induced angiosarcoma Radiotherapy Breast-conserving surgery Breast cancer Paclitaxel therapy Adjuvant therapy of angiosarcoma
発行日	2020-01-16
出版物タイトル	Surgical Case Reports
巻	6巻
号	1号
出版者	SpringerOpen
開始ページ	25
ISSN	2198-7793
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	31950295
DOI	10.1186/s40792-020-0790-7
Web of Science KeyUT	000513920900001
関連URL	isVersionOf https://doi.org/10.1186/s40792-020-0790-7

Evaluation of Therapeutic Target Gene Expression Based on Residual Cancer Burden Classification After Neoadjuvant Chemotherapy for HER2-Negative Breast Cancer

フルテキストURL	fulltext.pdf
著者	Takahashi, Yuko\| Iwamoto, Takayuki\| Suzuki, Yoko\| Kajiwara, Yukiko\| Hatono, Minami\| Tsukioki, Takahiro\| Kawada, Kengo\| Kochi, Mariko\| Ikeda, Hirokuni\| Shien, Tadahiko\| Taira, Naruto\| Matsuoka, Junji\| Doihara, Hiroyoshi\| Toyooka, Shinichi\|
キーワード	Gene expression Hormone receptor positive Residual tumor burden Targeted therapy Triple negative
発行日	2020-04
出版物タイトル	Clinical Breast Cancer
巻	20巻
号	2号
出版者	Elsevier
開始ページ	117
終了ページ	124
ISSN	1526-8209
NCID	AA11694891
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31570267
DOI	10.1016/j.clbc.2019.07.001
Web of Science KeyUT	000529805200021
関連URL	isVersionOf https://doi.org/10.1016/j.clbc.2019.07.001

Development of a Japanese version of the BREAST-Q and the traditional psychometric test of the mastectomy module for the assessment of HRQOL and patient satisfaction following breast surgery

フルテキストURL	BreastCancer_24_4_593.pdf BreastCancer_24_4_593_tbl_fig.pdf
著者	Saiga, Miho\| Taira, Naruto\| Kimata, Yoshihiro\| Watanabe, Satoko\| Mukai, Yuko\| Shimozuma, Kojiro\| Mizoo, Taeko\| Nogami, Tomohiro\| Iwamoto, Takayuki\| Motoki, Takayuki\| Shien, Tadahiko\| Matsuoka, Junji\| Doihara, Hiroyoshi\|
キーワード	BREAST-Q Breast cancer Breast reconstruction Health-related quality of life Satisfaction
発行日	2017-03
出版物タイトル	Breast Cancer
巻	24巻
号	2号
出版者	Japanese Breast Cancer Society
開始ページ	288
終了ページ	298
ISSN	1340-6868
NCID	AA1103354X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	27179527
DOI	10.1007/s12282-016-0703-6
Web of Science KeyUT	000395524900012
関連URL	isVerionOf https://doi.org/10.1007/s12282-016-0703-6

A Phase I Trial of 100mg/m2 Docetaxel in Patients with Advanced or Recurrent Breast Cancer

JaLCDOI	10.18926/AMO/54607
フルテキストURL	70_5_425.pdf
著者	Tamura, Tomoki\| Hirata, Taizo\| Tabata, Masahiro\| Hinotsu, Shiro\| Hamada, Akinobu\| Motoki, Takayuki\| Iwamoto, Takayuki\| Mizoo, Taeko\| Nogami, Tomohiro\| Shien, Tadahiko\| Taira, Naruto\| Matsuoka, Junji\| Doihara, Hiroyoshi\|
抄録	Docetaxel is a standard treatment for patients with advanced or recurrent breast cancer. The recommended dose is 60 to 100 mg/m2. Previous study have shown that the tumor response rates of patients who received docetaxel monotherapy at doses of 60, 75, and 100 mg/m2 were 22.1% , 23.3% , and 36.0% , respectively, and there was a significant relationship between the dose and response. In Europe and the United States, docetaxel is approved at a dose of 100 mg/m2, and Japanese guidelines also recommend a dose of 100 mg/m2. However, the approved dose in Japan is up to 75 mg/m2. We have launched a phase I trial evaluating 100 mg/m2 docetaxel in patients with advanced or relapsed breast cancer. The major eligibility criteria are as follows: age ≥20 years, pathologically diagnosed breast cancer, recurrent or advanced breast cancer, a good performance status, and HER2 [human epidermal growth factor receptor 2] negative. The primary endpoint is demonstrated safety of 100 mg/m2 docetaxel. This study will clarify whether 100mg/m2 docetaxel can be administrated safely in Japanese patients with advanced or recurrent breast cancer.
キーワード	breast cancer phase I trial docetaxel
Amo Type	Clinical Study Protocols
出版物タイトル	Acta Medica Okayama
発行日	2016-10
巻	70巻
号	5号
出版者	Okayama University Medical School
開始ページ	425
終了ページ	427
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27777441
Web of Science KeyUT	000388098700018

Correlation between 18F-fluorodeoxyglucose Positron Emission Tomography/computed Tomography and Clinicopathological Features in Invasive Ductal Carcinoma of the Breast

JaLCDOI	10.18926/AMO/53907
フルテキストURL	69_6_333.pdf
著者	Ito, Maiko\| Shien, Tadahiko\| Kaji, Mitsumasa\| Mizoo, Taeko\| Iwamoto, Takayuki\| Nogami, Tomohiro\| Motoki, Takayuki\| Taira, Naruto\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\|
抄録	We evaluated the usefulness of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) examinations to predict the pathological features in primary breast cancer. In particular, we evaluated the correlation between the maximum standardized uptake values (SUVmax) obtained by 18F-FDG PET/CT and the Ki67 expression in estrogen receptor (ER)-positive invasive ductal carcinoma (IDC). Primary IDC patients operated between March 2009 and July 2013 at Okayama University Hospital were enrolled. We evaluated the correlations between the SUVmax and age, postoperative pT, histological grade, lymph vascular invasion, status of hormone receptor, human epidermal growth factor receptor 2 (HER2), Ki67 expression and node status. The Ki67 expression was classified as high (>14%) versus low (<14%). We enrolled 138 patients with IDC. Their median SUVmax was 3.85 (range:0-52.57). In a univariate analysis, the SUVmax was significantly related to age, pT, histological grade, lymphovascular invasion, hormone receptor status, HER2 status, node status and Ki67. In the 113 patients with ER-positive IDC, there was a significant correlation between Ki67 and SUVmax (p=0.0030). The preoperative 18F-FDG PET/CT results of IDC patients had significant relationships with pathological status parameters. The determination of the preoperative SUVmax might help classify Luminal A and Luminal B patients among luminal-type breast cancer patients.
キーワード	breast cancer invasive ductal carcinoma 18F-fluorodeoxyglucose positron emission tomography/computed tomography maximum standardized uptake values clinicopathological features
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-12
巻	69巻
号	6号
出版者	Okayama University Medical School
開始ページ	333
終了ページ	338
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26690243
Web of Science KeyUT	000368434500002

Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case-control study in Japanese women

著者	Mizoo, Taeko\| Taira, Naruto\| Nishiyama, Keiko\| Nogami, Tomohiro\| Iwamoto, Takayuki\| Motoki, Takayuki\| Shien, Tadahiko\| Matsuoka, Junji\| Doihara, Hiroyoshi\| Ishihara, Setsuko\| Kawai, Hiroshi\| Kawasaki, Kensuke\| Ishibe, Youichi\| Ogasawara, Yutaka\| Komoike, Yoshifumi\| Miyoshi, Shinichiro\|
発行日	2013-12-01
出版物タイトル	BMC Cancer
巻	13巻
資料タイプ	学術雑誌論文

Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers

著者	Itoh, Mitsuya\| Iwamoto, Takayuki\| Matsuoka, Junji\| Nogami, Tomohiro\| Motoki, Takayuki\| Shien, Tadahiko\| Taira, Naruto\| Niikura, Naoki\| Hayashi, Naoki\| Ohtani, Shoichiro\| Higaki, Kenji\| Fujiwara, Toshiyoshi\| Doihara, Hiroyoshi\| Symmans, W. Fraser\| Pusztai, Lajos\|
発行日	2014-01
出版物タイトル	Breast Cancer Research and Treatment
巻	143巻
号	2号
資料タイプ	学術雑誌論文

DNA methylation status of REIC/Dkk-3 gene in human malignancies

著者	Hayashi, Tatsuro\| Asano, Hiroaki\| Toyooka, Shinichi\| Tsukuda, Kazunori\| Soh, Junichi\| Shien, Tadahiko\| Taira, Naruto\| Maki, Yuho\| Tanaka, Norimitsu\| Doihara, Hiroyoshi\| Nasu, Yasutomo\| Huh, Nam-ho\| Miyoshi, Shinichiro\|
発行日	2012-05
出版物タイトル	Journal of Cancer Research and Clinical Oncology
巻	138巻
号	5号
資料タイプ	学術雑誌論文

早期乳癌におけるOne-step Nucleic Acid Amplification(OSNA)法によるセンチネルリンパ節転移診断の検討

タイトル（別表記）	Evaluation of a one-step nucleic acid amplification (OSNA) assay for sentinel lymph node metastases in early breast cancer
フルテキストURL	126_25.pdf
著者	溝尾妙子\| 枝園忠彦\| 伊藤麻衣子\| 野上智弘\| 岩本高行\| 元木崇之\| 平成人\| 松岡順治\| 土井原博義\|
抄録	Introduction: The one-step nucleic acid amplification (OSNA) assay is a new method to detect sentinel lymph node (SLN) metastases using cytokeratin 19 (CK19) mRNA in early breast cancer. Here we retrospectively analyzed the advantages and disadvantages of the OSNA assay. 　Methods: In a trial period, SLNs were divided into two sections, and we examined one side using the OSNA assay. The other side was examined by pathologists. After this period, we examined whole SLNs using only the OSNA assay. The patients with positive nodes by OSNA assay and/or pathology required axillary dissection. 　Results: We examined 27 primary breast cancer patients (36 SLNs) during the trial period. The overall concordance rate between the OSNA assay and pathology results was 91%. In the later period, 157 patients (217 SLNs) were examined. The CK19-positive rate obtained by the OSNA assay was 16.5% (macrometastases OSNA (++) : 7.2%, micrometastases OSNA (+) : 9.2%). The non-SLN positive rate among the CK19-positivecases was 23%. The OSNA assay's false negative was one case in which the expression of CK-19 on the primary tumor and lymph node was not detected. 　Conclusions: Our OSNA assay results were comparable to those obtained using a conventional pathological technique. Pathologists and laboratory technicians could save time and effort by using the OSNA assay when seeking the precise diagnosis during surgery.
キーワード	OSNA法（OSNA method）センチネルリンパ節（sentinel lymph node） micrometastases CK-19
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	25
終了ページ	30
ISSN	0030-1558
関連URL	http://www.okayama-u.ac.jp/user/oma/
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.25

p53 Expression in Pretreatment Specimen Predicts Response to Neoadjuvant Chemotherapy Including Anthracycline and Taxane in Patients with Primary Breast Cancer.

JaLCDOI	10.18926/AMO/50409
フルテキストURL	67_3_165.pdf
著者	Shien, Tadahiko\| Kinoshita, Takayuki\| Seki, Kunihiko\| Yoshida, Miwa\| Hojo, Takashi\| Shimizu, Chikako\| Taira, Naruto\| Doihara, Hiroyoshi\| Akashi-Tanaka, Sadako\| Tsuda, Hitoshi\| Fujiwara, Yasuhiro\|
抄録	While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p＝0.045) and histological grade 3 (p＝0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC.
キーワード	breast cancer neoadjuvant chemotherapy predictors
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-06
巻	67巻
号	3号
出版者	Okayama University Medical School
開始ページ	165
終了ページ	170
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23804139
Web of Science KeyUT	Pretreatment Specimen Predicts

Association between Mammographic Breast Density and Lifestyle in Japanese Women

JaLCDOI	10.18926/AMO/50407
フルテキストURL	67_3_145.pdf
著者	Ishihara, Setsuko\| Taira, Naruto\| Kawasaki, Kensuke\| Ishibe, Youichi\| Mizoo, Taeko\| Nishiyama, Keiko\| Iwamoto, Takayuki\| Nogami, Tomohiro\| Motoki, Takayuki\| Shien, Tadahiko\| Matsuoka, Junji\| Doihara, Hiroyoshi\| Komoike, Yoshifumi\| Sato, Shuhei\| Kanazawa, Susumu\|
抄録	A high mammographic breast density is considered to be a risk factor for breast cancer. However, only a small number of studies on the association between breast density and lifestyle have been performed. A cross-sectional study was performed using a survey with 29 questions on life history and lifestyle. The breast density on mammography was classified into 4 categories following the BI-RADS criteria. The subjects were 522 women with no medical history of breast cancer. The mean age was 53.3 years old. On multivariate analysis, only BMI was a significant factor determining breast density in premenopausal women (parameter estimate, －0.403;p value, 0.0005), and the density decreased as BMI rose. In postmenopausal women, BMI (parameter estimate, －0.196;p value, 0.0143) and number of deliveries (parameter estimate, －0.388;p value, 0.0186) were significant factors determining breast density;breast density decreased as BMI and number of deliveries increased. Only BMI and number of deliveries were identified as factors significantly influencing breast density. BMI was inversely correlated with breast density before and after menopause, whereas the influence of number of deliveries on breast density was significant only in postmenopausal women in their 50 and 60s.
キーワード	breast cancer mammographic breast density life style body mass index
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-06
巻	67巻
号	3号
出版者	Okayama University Medical School
開始ページ	145
終了ページ	151
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23804137
Web of Science KeyUT	000320747900003
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/50646

Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1–3 lymph node metastases

著者	Nogami, Tomohiro\| Shien, Tadahiko\| Tanaka, Takehiro\| Nishiyama, Keiko\| Mizoo, Taeko\| Iwamto, Takayuki\| Ikeda, Hirokuni\| Taira, Naruto\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\|
発行日	2012-03-10
出版物タイトル	Breast Cancer
資料タイプ	学術雑誌論文

Ectopic Cervical Thymoma:A Case Report with 18F-fluorodeoxyglucose Positron Emission Tomography Findings

JaLCDOI	10.18926/AMO/48691
フルテキストURL	66_4_357.pdf
著者	Shien, Kazuhiko\| Shien, Tadahiko\| Soh, Junichi\| Ikeda, Hirokuni\| Nogami, Tomohiro\| Taira, Naruto\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\|
抄録	Ectopic thymoma is considered to arise from ectopic thymus tissue deposited as a result of the abnormal mislocalization of thymus tissue during the embryonic stage. An 86-year-old man visited our hospital with chief complaints of hoarseness and a mass in his anterior neck. A preoperative needle biopsy of the mass did not yield a definitive diagnosis. A positron emission tomography (PET) study revealed heterogeneous accumulation of ¹⁸F-fluorodeoxyglucose (FDG) in the tumor. The tumor, affecting the left sternocleidomastoid muscle, the recurrent laryngeal nerve, the internal carotid vein, and the brachiocephalic vein, was resected using a combination of a collar incision in the neck and a median incision in the sternum. Immunohistochemically, the tumor was diagnosed as an ectopic thymoma of the neck. To date, only a few cases of ectopic thymoma presenting with FDG accumulation have been reported. Our experience indicates that ectopic thymoma should be kept in mind during the differential diagnosis of neck tumors with FDG accumulation appearing on PET images.
キーワード	ectopic thymoma thyroid tumor positron emission tomography (PET)
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2012-08
巻	66巻
号	4号
出版者	Okayama University Medical School
開始ページ	357
終了ページ	361
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	22918209

Clinical Efficacy of Capecitabine and Cyclophosphamide (XC) in Patients with Metastatic Breast Cancer

JaLCDOI	10.18926/AMO/46848
フルテキストURL	65_4_231.pdf
著者	Shien, Tadahiko\| Doihara, Hiroyoshi\| Nishiyama, Keiko\| Masuda, Hiroko\| Nogami, Tomohiro\| Ikeda, Hirokuni\| Taira, Naruto\|
抄録	Combined low-dose therapy of oral capecitabine (Xeloda) and cyclophosphamide (XC) has been demonstrated to be useful for long-term control of lesions in patients with metastatic breast cancer (MBC) and is aimed at symptomatic alleviation and prolongation of survival. Here, a retrospective review was conducted of MBC patients administered XC at the Okayama University Hospital (OUH), to evaluate responses to XC, adverse events and time to progression (TTP). Twenty patients with MBC received XC between 2006 and 2009. With the exception of 2 elderly patients who were over the age of 70 at the initial examination, all of the patients had received prior treatment with an anthracycline and/or a taxane. No complete response (CR) cases were observed, but partial response (PR) was achieved in 6 patients (30%) and SD in 9 (45%), of whom 5 (20%) sustained SD status for >12 months. The median TTP was 6 months (range:3-27 mo.). Three patients developed Grade 3 adverse events (diarrhea, nausea and stomatitis), but no other patients developed adverse reactions causing interruption of the therapy. XC was safe even in previously treated and elderly MBC patients;moreover, it yielded remarkable clinical responses.
キーワード	metastatic breast cancer metronomic chemotherapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	231
終了ページ	237
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860529
Web of Science KeyUT	000294236700003

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