| フルテキストURL | fulltext20211004-1.pdf |
|---|---|
| 著者 | Fukui, Yuko| Hayano, Satoru| Kawanabe, Noriaki| Wang, Ziyi| Shimada, Akira| Saito, Megumu K.| Asaka, Isao| Kamioka, Hiroshi| |
| キーワード | iPS cell RPL5 cleft lip and palate chondrocyte Diamond-Blackfan Anemia |
| 備考 | This is an Accepted Manuscript of an article published by Wiley. This is the peer reviewed version of the following article: [Fukui, Y, Hayano, S, Kawanabe, N, Wang, Z, Shimada, A, Saito, MK, et al. Investigation of the molecular causes underlying physical abnormalities in Diamond-Blackfan anemia patients with RPL5 haploinsufficiency. Pathology International. 2021; 1-11. https://doi.org/10.1111/pin.13168], which has been published in final form at [https://doi.org/10.1111/pin.13168]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-ArchivedVersions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wileyor by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked toWiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof bythird parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| 発行日 | 2021-9-29 |
| 出版物タイトル | Pathology International |
| 巻 | 2021巻 |
| 出版者 | Wiley |
| 開始ページ | 1 |
| 終了ページ | 11 |
| ISSN | 1320-5463 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd |
| 論文のバージョン | author |
| DOI | 10.1111/pin.13168 |
| 関連URL | isVersionOf https://doi.org/10.1111/pin.13168 |
| フルテキストURL | fulltext20210428_3.pdf |
|---|---|
| 著者 | Shimada, Akira| |
| キーワード | Down syndrome Acute myeloid leukemia Acute megakaryoblastic leukemia Transient abnormal myelopoiesis Acute lymphoblastic leukemia Solid tumor Cancer predisposition syndrome GATA1 Down syndrome critical region 1 |
| 発行日 | 2021-01-21 |
| 出版物タイトル | Pediatric Hematology Oncology Journal |
| 出版者 | Elsevier |
| ISSN | 24681245 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1016/j.phoj.2021.01.001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.phoj.2021.01.001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ishida, Hisashi| Iguchi, Akihiro| Aoe, Michinori| Nishiuchi, Ritsuo| Matsubara, Takehiro| Keino, Dai| Sanada, Masashi| Shimada, Akira| |
| キーワード | leukemia pediatric acute myeloid leukemia molecular genetics precision medicine |
| 発行日 | 2020-11 |
| 出版物タイトル | Biomedical Reports |
| 巻 | 13巻 |
| 号 | 5号 |
| 出版者 | Spandidos Publications |
| 開始ページ | 46 |
| ISSN | 2049-9434 |
| NCID | AA12610729 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 32934818 |
| DOI | 10.3892/br.2020.1353 |
| Web of Science KeyUT | 000606302400012 |
| 関連URL | isVersionOf https://doi.org/10.3892/br.2020.1353 |
| JaLCDOI | 10.18926/AMO/61215 |
|---|---|
| フルテキストURL | 74_6_545.pdf |
| 著者 | Tatebe, Yasuhisa| Kanamitsu, Kiichiro| Kanzaki, Hirotaka| Ishida, Hisashi| Fujiwara, Kaori| Washio, Kana| Kitamura, Yoshihisa| Sendo, Toshiaki| Shimada, Akira| Tsukahara, Hirokazu| |
| 抄録 | Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner. |
| キーワード | methotrexate polymorphism drug elimination acute kidney injury acute lymphoblastic leukemia |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-12 |
| 巻 | 74巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 545 |
| 終了ページ | 550 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33361876 |
| Web of Science KeyUT | 000601203600012 |
| NAID | 120006948942 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Oyama, Takanori| Noda, Takuo| Washio, Kana| Shimada, Akira| |
| キーワード | growing teratoma syndrome immature teratoma ovarian tumor pediatric |
| 発行日 | 2020-09-18 |
| 出版物タイトル | Medicine |
| 巻 | 99巻 |
| 号 | 38号 |
| 出版者 | Lippincott, Williams & Wilkins |
| 開始ページ | e22297 |
| ISSN | 0025-7974 |
| NCID | AA00728867 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 32957389 |
| DOI | 10.1097/MD.0000000000022297 |
| Web of Science KeyUT | 000579298600086 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000022297 |
| JaLCDOI | 10.18926/AMO/55208 |
|---|---|
| フルテキストURL | 71_3_249.pdf |
| 著者 | Washio, Kana| Muraoka, Michiko| Kanamitsu, Kiichiro| Oda, Megumi| Shimada, Akira| |
| 抄録 | We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH. |
| キーワード | langerhans cell histiocytosis (LCH) hemophagocytic lymphohistiocytosis (HLH) hematopoietic stem cell transplantation (HSCT) reduced-intensity conditioning (RIC) refractory |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 254 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655945 |
| 著者 | Iwasaki, Yuka| Nishiuchi, Rituo| Aoe, Michinori| Takahashi, Takahide| Watanabe, Hirokazu| Tokorotani, Chiho| Kikkawa, Kiyoshi| Shimada, Akira| |
|---|---|
| 発行日 | 2017-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 71巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/54829 |
| JaLCDOI | 10.18926/AMO/54815 |
|---|---|
| フルテキストURL | 70_6_503.pdf |
| 著者 | Kanazawa, Yui| Yamashita, Yuka| Fujiwara, Mitsuhiro| Muraoka, Michiko| Washio, Kana| Kanamitsu, Kiichiro| Ishida, Hisashi| Nakano, Takae| Yamada, Miho| Horibe, Keizo| Tanaka, Takehiro| Yoshino, Tadashi| Shimada, Akira| |
| 抄録 | Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10–30 of cases of non-Hodgkin lymphoma, and the ALCL99 study reported 60–75 disease-free survival; however, a relatively high relapse rate was observed (25–30 ). We report 2 patients with Stage III ALCL who relapsed 6–18 months after the end of ALCL99 chemotherapy. A retrospective molecular analysis identified the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion gene in the first diagnostic bone marrow samples taken from both patients. However, antibodies against the ALK protein appeared to be relatively low in the serum of both patients (×100 and ×750). An increase in chemotherapy intensity may be beneficial if Stage III ALCL patients are shown to be NPM-ALK chimera-positive in the first diagnostic bone marrow sample. |
| キーワード | ALCL NPM-ALK fusion lymphoma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-12 |
| 巻 | 70巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 503 |
| 終了ページ | 506 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28003677 |
| JaLCDOI | 10.18926/AMO/52408 |
|---|---|
| フルテキストURL | 68_2_119.pdf |
| 著者 | Takeda, Akiko| Shimada, Akira| Hamamoto, Kazuko| Yoshino, Syuuji| Nagai, Tomoko| Fujii, Yousuke| Yamada, Mutsuko| Nakamura, Yoshimi| Watanabe, Toshiyuki| Watanabe, Yuki| Yamamoto, Yuko| Sakakibara, Kanae| Oda, Megumi| Morishima, Tsuneo| |
| 抄録 | Acute megakaryocytic leukemia (AMKL) with t(1;22)(p13;q13) is a distinct category of myeloid leukemia by WHO classification and mainly reported in infants and young children. Accurate diagnosis of this type of AMKL can be difficult, because a subset of patients have a bone marrow (BM) blast percentage of less than 20% due to BM fibrosis. Therefore, it is possible that past studies have underestimated this type of AMKL. We present here the case of a 4-month-old female AMKL patient who was diagnosed by presence of the RBM15-MKL1 (OTT-MAL) fusion transcript by RT-PCR. In addition, we monitored RBM15-MKL1 fusion at several time points as a marker of minimal residual disease (MRD), and found that it was continuously negative after the first induction chemotherapy even by nested RT-PCR. Detection of the RBM15-MKL1 fusion transcript thus seems to be useful for accurate diagnosis of AMKL with t(1;22)(p13;q13). We recommend that the RBM15-MKL1 fusion transcript be analyzed for all suspected AMKL in infants and young children. Furthermore, monitoring of MRD using this fusion transcript would be useful in treatment of AMKL with t(1;22)(p13;q13). |
| キーワード | AMKL infant RBM15-MKL1 OTT-MAL |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-04 |
| 巻 | 68巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 119 |
| 終了ページ | 123 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24743787 |
| Web of Science KeyUT | 000334652700007 |