ID | 63940 |
フルテキストURL | |
著者 |
Nishikori, Asami
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Nishimura, Midori Filiz
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Nishimura, Yoshito
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
publons
researchmap
Otsuka, Fumio
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
Kaken ID
publons
researchmap
Maehama, Kanna
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Ohsawa, Kumiko
Department of Pathology, Saitama Medical Center, Saitama Medical University
Momose, Shuji
Department of Pathology, Saitama Medical Center, Saitama Medical University
Nakamura, Naoya
Department of Pathology, Tokai University School of Medicine
Sato, Yasuharu
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
ORCID
Kaken ID
researchmap
|
抄録 | Idiopathic multicentric Castleman disease (iMCD) is a type of Castleman disease that is not related to KSHV/HHV8 infection. Currently, iMCD is classified into iMCD-TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly) and iMCD-NOS (not otherwise specified). The former has been established as a relatively homogeneous disease unit that has been recently re-defined, while the latter is considered to be a heterogeneous disease that could be further divided into several subtypes. In 1980, Mori et al. proposed the concept of idiopathic plasmacytic lymphadenopathy (IPL), a disease presenting with polyclonal hypergammaglobulinemia and a sheet-like proliferation of mature plasma cells in the lymph nodes. Some researchers consider IPL to be a part of iMCD-NOS, although it has not been clearly defined to date. This is the first paper to analyze iMCD-NOS clinicopathologically, to examine whether IPL forms a uniform disease unit in iMCD. Histologically, the IPL group showed prominent plasmacytosis and the hyperplasia of germinal centers, while the non-IPL group showed prominent vascularity. Clinically, the IPL group showed significant thrombocytosis and elevated serum IgG levels compared to the non-IPL group (p = 0.007, p < 0.001, respectively). Pleural effusion and ascites were less common in the IPL group (p < 0.001). The IPL group was more likely to have an indolent clinical course and a good response to the anti-IL-6 receptor antibody, while the non-IPL counterpart frequently required more aggressive medical interventions. Thus, the IPL group is a clinicopathologically uniform entity that forms an independent subtype of iMCD.
|
キーワード | Castleman disease
idiopathic multicentric Castleman disease
idiopathic plasmacytic lymphadenopathy
plasma cell morphology
|
発行日 | 2022-09-07
|
出版物タイトル |
International Journal Of Molecular Sciences
|
巻 | 23巻
|
号 | 18号
|
出版者 | MDPI
|
開始ページ | 10301
|
ISSN | 1422-0067
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © 2022 by the authors.
|
論文のバージョン | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/ijms231810301
|
ライセンス | https://creativecommons.org/licenses/by/4.0/
|
助成機関名 |
Japan Society for the Promotion of Science
|
助成番号 | JP 20K07407
|