ID | 61268 |
フルテキストURL | |
著者 |
Nishimura, Midori Filiz
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Igawa, Takuro
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Gion, Yuka
Division of Pathophysiology, Okayama University Graduate School of Health Sciences
Kaken ID
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Tomita, Sakura
Department of Pathology, Tokai University School of Medicine
Inoue, Dai
Department of Radiology, Kanazawa University Graduate School of Medical Sciences
Izumozaki, Akira
Department of Radiology, Kanazawa University Graduate School of Medical Sciences
Ubara, Yoshifumi
Nephrology Center, Toranomon Hospital Kajigaya
Nishimura, Yoshito
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
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Yoshino, Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kaken ID
publons
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Sato, Yasuharu
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
Kaken ID
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抄録 | Plasma cell type idiopathic multicentric Castleman disease (PC-iMCD) occasionally manifests as parenchymal lung disease. This study aimed to elucidate the detailed clinicopathological features of lung lesions in PC-iMCD and compare the findings with those in immunoglobulin (Ig) G4-related disease (IgG4-RD), the most difficult differential diagnosis of PC-iMCD. We analyzed the clinicopathological findings and immunohistochemical expression patterns of interleukin-6 (IL-6) and Igs in lung specimens from 16 patients with PC-iMCD and 7 patients with IgG4-RD. Histologically, pulmonary PC-iMCD could not be differentiated from IgG4-RD based on lesion distribution patterns, the number of lymphoid follicles and obliterative vasculitis, or fibrosis types. The eosinophil count was higher in the IgG4-RD group than in the PC-iMCD group (p = 0.004). The IgG4/IgG-positive cell ratio was significantly higher in the IgG4-RD group (p < 0.001). The IgA-positive cell count and IL-6 expression intensity were higher in the PC-iMCD group than in the IgG4-RD group (p < 0.001). Based on these findings, we proposed a new diagnostic approach to differentiate lung lesions of PC-iMCD and IgG4-RD. Our approach can be utilized to stratify patients with suspected lung-dominant PC-iMCD to identify candidates for strong immunosuppressive treatment, including IL-6 blockade, at an early stage.
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キーワード | plasma cell type idiopathic multicentric Castleman disease
IL-6
IgG4-related disease
immunohistochemistry
hyper IL-6 syndrome
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発行日 | 2020-12-10
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出版物タイトル |
Journal of Personalized Medicine
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巻 | 10巻
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号 | 4号
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出版者 | MDPI
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開始ページ | 269
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ISSN | 2075-4426
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2020 by the authors.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/jpm10040269
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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助成機関名 |
日本学術振興会
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助成番号 | JP 20K07407
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