ID | 58233 |
フルテキストURL | |
著者 |
Katayama, Akihiro
Diabetes Center, Okayama University Hospital
Tone, Atsuhito
Diabetes Center, Okayama Saiseikai General Hospital
Watanabe, Mayu
Department of Primary Care and Medical Education, Okayama University
Teshigawara, Sanae
Diabetes Center, Okayama Saiseikai General Hospital
Miyamoto, Satoshi
Center for Innovative Clinical Medicine, Okayama University Hospital
Kaken ID
Eguchi, Jun
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Nakatsuka, Atsuko
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
publons
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Shikata, Kenichi
Center for Innovative Clinical Medicine, Okayama University Hospital
ORCID
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Wada, Jun
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
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抄録 | Aims/introduction
The predictive low glucose management (PLGM) system was introduced in March 2018 in Japan. Although there are some reports demonstrating the benefit of PLGM in preventing hypoglycemia, no data are currently available in Japanese patients with type 1 diabetes mellitus (T1DM). The aim of the present study is to evaluate the effect of PLGM with sensor-augmented pump therapy in the prevention of hypoglycemia in Japanese patients.
Materials and methods
We included 16 patients with T1DM who used the MiniMed®640G system after switching from the MiniMed®620G system. We retrospectively analysed the data of the continuous glucose monitoring system in 1 month after switching to MiniMed®640G.
Results
The area under the curve (AUC) of hypoglycemia of < 70 mg/dL was lowered from 0.42 ± 0.43 mg/dL day to 0.18 ± 0.18 mg/dL day (P = 0.012). Correspondingly, the duration of severe hypoglycemia (< 54 mg/dL) was reduced significantly from 15.3 ± 21.7 min/day to 4.8 ± 6.9 min/day (P = 0.019). The duration of hypoglycemia was reduced, but the reduction was not significant. Regarding the AUC for hyperglycemia > 180 mg/dL and the duration of hyperglycemia did not change. With the PLGM function, 79.3% of the predicted hypoglycemic events were avoided.
Conclusions
The hypoglycemia avoidance rate was comparable to those in previous reports. In addition, we demonstrated that PLGM can markedly suppress severe hypoglycemia without deteriorating glycemic control in Japanese T1DM patients. It is necessary to further investigate the effective use of the PLGM feature such as establishing a lower limit and the timing of resumption.
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キーワード | Hypoglycemia
Predictive low glucose management (PLGM)
Type 1 diabetes mellitus (T1DM)
Sensor-augmented pump therapy (SAP)
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備考 | This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13340-019-00408-7.
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発行日 | 2019-09-16
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出版物タイトル |
Diabetology International
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巻 | 11巻
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号 | 2号
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出版者 | Springer
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開始ページ | 97
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終了ページ | 104
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ISSN | 2190-1678
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NCID | AA12503387
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | author
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PubMed ID | |
NAID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1007/s13340-019-00408-7
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