ID | 61874 |
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Watanabe, Haruki
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
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publons
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Sada, Ken-ei
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
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Harigai, Masayoshi
Department of Rheumatology, Tokyo Women’s Medical University School of Medicine
Amano, Koichi
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University
Dobashi, Hiroaki
Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University
Takasaki, Yoshinari
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Fujimoto, Shouichi
Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki
Atsumi, Tatsuya
Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
Yamagata, Kunihiro
Department of Nephrology, Faculty of Medicine, University of Tsukuba
Homma, Sakae
Department of Advanced and Integrated Interstitial Lung Diseases Research, School of Medicine, Toho University
Arimura, Yoshihiro
Department of Nephrology and Rheumatology, Kyorin University School of Medicine
Research Committee of Intractable Vasculitis Syndrome (JPVAS) & Research Committee of Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan
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抄録 | A novel patient cluster in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) may be identified in Japan. We performed multiple correspondence and cluster analysis regarding 427 clinically diagnosed AAV patients excluding eosinophilic granulomatosis with polyangiitis. Model 1 included the ANCA phenotype, items of the Birmingham Vasculitis Activity Score, and interstitial lung disease; model 2 included serum creatinine (s-Cr) and C-reactive protein (CRP) levels with model 1 components. In seven clusters determined in model 1, the ANCA-negative (n=8) and proteinase 3-ANCA-positive (n=41) groups emerged as two distinct clusters. The other five myeloperoxidase-ANCA-positive clusters were characterized by ear, nose, and throat (ENT) (n=47); cutaneous (n=36); renal (n=256), non-renal (n=33); and both ENT and cutaneous symptoms (n=6). Four clusters in model 2 were characterized by myeloperoxidase-ANCA negativity (n=42), without s-Cr elevation (<1.3 mg/dL) (n=157), s-Cr elevation (
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発行日 | 2021-03-04
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出版物タイトル |
Scientific Reports
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巻 | 11巻
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号 | 1号
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出版者 | Nature Research
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ISSN | 2045-2322
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | publisher
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関連URL | isVersionOf https://doi.org/10.1038/s41598-021-84627-6
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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