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ID 69040
フルテキストURL
著者
Mitsui, Masao Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Sadahira, Takuya Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Nagasaki, Naoya Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Maruyama, Yuki
Sekito, Takanori Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Iwata, Takehiro Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID
Katayama, Satoshi Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Bekku, Kensuke Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Araki, Motoo Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
抄録
Objective: We evaluated the incidence of and risk factors for postoperative infections after robotic-assisted radical prostatectomy (RARP) according to the type and duration of prophylactic antibiotic administration.
Methods: A total of 1038 patients underwent RARP at our institution from 2010 to 2021; 1026 patients (201 in the cefazolin [CEZ] group and 825 in the ampicillin/sulbactam [ABPC/SBT] group) were analyzed, and 12 who used other antibiotics were excluded. The primary endpoint was the incidence of urinary tract infection (UTI), surgical site infection (SSI), and remote infection (RI). T-tests, propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were performed. Multivariate logistic regression analysis was performed to evaluate the effect of type and duration of prophylactic antibiotic administration.
Results: The incidence of UTI was 2.5% (5/201) in the CEZ group and 3.2% (26/825) in the ABPC/SBT group, with no significant difference between groups (p = 0.622). The rates of SSI and RI were comparable between groups (p = 0.680 and 0.906, respectively). Although the duration of antimicrobial therapy was longer in the ABPC/SBT group (p < 0.001), there was no significant difference in the incidence of UTI/SSI/RI after PSM and IPTW (all p > 0.05). Multivariate logistic regression analysis showed that neither the type of antibiotic nor the duration of administration affected the incidence of UTI/SSI/RI.
Conclusion: The risk of postoperative UTI/SSI/RI after RARP did not change with the type and duration of antimicrobial therapy.
キーワード
cefazolin
postoperative infections
prophylactic antibiotics
prostate
robotic-assisted radical prostatectomy
発行日
2024-11-18
出版物タイトル
International Journal of Urology
32巻
3号
出版者
Wiley
開始ページ
258
終了ページ
263
ISSN
0919-8172
NCID
AA11042471
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
著作権者
© 2024 The Author(s).
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1111/iju.15635
ライセンス
http://creativecommons.org/licenses/by/4.0/
Citation
Mitsui, M., Sadahira, T., Nagasaki, N., Maruyama, Y., Sekito, T., Iwata, T., Katayama, S., Bekku, K. and Araki, M. (2025), Postoperative infections after robotic-assisted radical prostatectomy in a single large institution: Effect of type and duration of prophylactic antibiotic administration. Int. J. Urol., 32: 258-263. https://doi.org/10.1111/iju.15635