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ID 46919
フルテキストURL
著者
Kitamatsu, Mizuki Department of Medical and Bioengineering, Graduate School of Natural Science and Technology
Kurami, Shunsuke Department of Medical and Bioengineering, Graduate School of Natural Science and Technology
Ohtsuki, Takashi Department of Medical and Bioengineering, Graduate School of Natural Science and Technology ORCID Kaken ID researchmap
Sisido, Masahiko Department of Medical and Bioengineering, Graduate School of Natural Science and Technology
抄録
To investigate the antisense effect of a pyrrolidine-based oxy-peptide nucleic acid (POPNA), we carried out the LacZ reporter assay using a 12-mer trans-l-POPNA conjugated with a cell-penetrating peptide (antisense reagent). The antisense effect of the conjugated POPNA (inhibition of LacZ activity) was comparable to that shown by a Nielsen-type peptide nucleic acid. Furthermore, the conjugated POPNA could switch the LacZ activity over a wide range of ambient temperatures.
キーワード
Peptide nucleic acid
Cell-penetrating peptide
Antisense effect
発行日
2011-01
出版物タイトル
Bioorganic & Medicinal Chemistry Letters
21巻
1号
出版者
Pergamon-Elsevier Science Ltd,
開始ページ
225
終了ページ
227
ISSN
0960-894X
NCID
AA1079577X
資料タイプ
学術雑誌論文
言語
English
著作権者
© 2010 Elsevier Ltd. All rights reserved.
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