ID | 63344 |
フルテキストURL | |
著者 |
Tsumura, Munechika
Department of Otolaryngology Head and Neck Surgery, Kagawa Rosai Hospital
Makihara, Seiichiro
Department of Otolaryngology Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
Nishikori, Asami
Division of Pathophysiology, Graduate School of Health Sciences, Okayama University
Gion, Yuka
Division of Pathophysiology, Graduate School of Health Sciences, Okayama University
Kaken ID
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Morito, Toshiaki
Department of Pathology, Kagawa Rosai Hospital
Miyamoto, Shotaro
Department of Otolaryngology Head and Neck Surgery, Kagawa Rosai Hospital
Naito, Tomoyuki
Department of Otorhinolaryngology, Kagawa Prefectural Central Hospital
Uraguchi, Kensuke
Department of Otolaryngology Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
Oka, Aiko
Department of Otorhinolaryngology, School of Medicine, International University of Health and Welfare
Tachibana, Tomoyasu
Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
Orita, Yorihisa
Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kumamoto University
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Kariya, Shin
Department of Otolaryngology Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
ORCID
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Okano, Mitsuhiro
Department of Otorhinolaryngology, School of Medicine, International University of Health and Welfare
Kaken ID
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Ando, Mizuo
Department of Otolaryngology Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
Sato, Yasuharu
Department of Pathology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
ORCID
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抄録 | Sinonasal inverted papilloma (SNIP) can recur; however, the factors related to tumor recurrence remain unclear. This study aimed to analyze risk factors, including human papillomavirus (HPV) infection, as well as other factors associated with SNIP recurrence. Thirty-two patients who were diagnosed with SNIP and underwent surgery between 2010 and 2019 were enrolled: 24 men and 8 women, with a mean age of 59.2 years. The mean follow-up was 57.3 months. Demographics and information about history of smoking, diabetes mellitus (DM), hypertension, allergic rhinitis, alcohol consumption, tumor stage, surgical approach, and recurrence were reviewed retrospectively. Specimens were investigated using polymerase chain reaction to detect HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11). Seven patients (21.9%) experienced recurrence. HPV DNA was detected in five (15.6%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 3). Patients with recurrence of SNIP had a higher proportion of young adults and displayed higher rates of HPV infection, DM, and advanced tumor stage than those without recurrence. HPV infection, young adulthood, DM, and advanced tumor stage could be associated with a high recurrence rate, which suggests that patients with these risk factors could require close follow-up after surgery.
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キーワード | HPV infection
sinonasal inverted papilloma
diabetes mellitus
young adult
tumor stage
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発行日 | 2022-02-10
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出版物タイトル |
Diagnostics
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巻 | 12巻
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号 | 2号
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出版者 | MDPI
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開始ページ | 454
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ISSN | 2075-4418
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2022 by the authors.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/diagnostics12020454
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ライセンス | https://creativecommons.org/licenses/by/4.0/
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