ID | 31747 |
JaLCDOI | |
フルテキストURL | |
著者 |
Wakiguchi, Hiroshi
Kochi Medical School
Fujieda, Mikiya
Kochi Medical School
Matsumoto, Kenji
Kochi Medical School
Ohara, Yuji
Kochi Medical School
Kuroiwa, Yoshio
Kochi Medical School
Wakiguchi, Akiko
Okayama University
Shiraishi, Taisuke
Okayama University
Kurashige, Takanobu
Okayama University
Kitamura, Isamu
Okayama University
|
抄録 | Antibody activity, especially that involved in the reaction of antibody-dependent cell-mediated cytotoxicity (ADCC), of five commercially available human gammaglobulin preparations (standard, pepsin-treated, plasmin-treated, polyethylene glycol-fractionated and S-sulfonated gammaglobulin) was measured. All these gammaglobulin preparations had high titers of hemagglutination inhibition and neutralizing antibody against measles virus. In ADCC reaction, the pepsin-treated gammaglobulin preparation showed no antibody activity. The standard gammaglobulin preparation showed weak activity only when highly diluted. The remaining three preparations showed high activity. Though the S-sulfonated gammaglobulin preparation showed no activity in ADCC reaction, it showed high activity after reconversion by means of oxidation and reduction in vitro. The plasmin-treated gammaglobulin preparation showed greater activity than the polyethylene glycol-fractionated preparation of the optimal concentration. In ADCC tests using the plasmin-treated gammaglobulin preparation, K cell activity was strongly inhibited by Hg (thimerosal), while, in those using the standard gammaglobulin preparation, the activity was hardly influenced by Hg, suggesting that the low ADCC activity of the standard gammaglobulin preparation of high concentrations was due to the inhibitory effect of aggregated immunoglobulin G molecules. |
キーワード | antibody-dependent cell-mediated cytotoxicity
measles
immunology
gammaglobulin preparation
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1987-04
|
巻 | 41巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
開始ページ | 71
|
終了ページ | 79
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |