ID | 62837 |
フルテキストURL | |
著者 |
Honda, Hiroyuki
Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Hagiya, Hideharu
Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
ORCID
Kaken ID
researchmap
Higashionna, Tsukasa
Department of Pharmacy, Okayama University Hospital
Haruki, Yuto
Department of Pharmacy, Tsuyama Chuo Hospital
Haruki, Mai
Department of Pharmacy, Tsuyama Chuo Hospital
Kajita, Shiho
Department of Pharmacy, Okayama City Hospital
Mukuda, Kengo
Department of Internal Medicine, Yonago Medical Center
Yokoyama, Yuji
Department of Pharmacy, Marugame Medical Center
Nakano, Yasuhiro
Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Ogawa, Hiroko
Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Kaken ID
publons
Morimoto, Yasuyo
Department of Pharmacy, Kasaoka City Hospital
Hanayama, Yoshihisa
Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
publons
Kanda, Setsuko
Department of Nursing, Okayama Kyokuto Hospital
Kataoka, Hitomi
Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Muguruma, Hitomi
Department of Pharymacy, Okayama Memorial Hospital
Otsuka, Fumio
Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
ORCID
Kaken ID
publons
researchmap
|
抄録 | To encourage and guide antimicrobial stewardship team (AST) activity and promote appropriate antibiotic use, we studied the impact of day of the week on the initiation and discontinuation of antibiotic administration. This was a multicenter observational study conducted at 8 Japanese hospitals from April 1 to September 30, 2019, targeting patients who underwent treatment with broad-spectrum antibiotics, such as anti-methicillin-resistant Staphylococcus aureus agents and anti-pseudomonal agents. We compared the weekly numbers of initiations and discontinuations of antibiotic prescription on each day of the week or on the days after a holiday. There was no statistical difference in the number of antibiotic initiations on both weekdays and the day after a holiday. However, antibiotic discontinuation was significantly higher from Tuesday onward than Monday and from the second day than the first day after a holiday. Similar trends were observed regardless of the categories of antibiotics, hospital and admission ward, and AST activity. This study suggests that broad-spectrum antibiotics tend to be continued during weekends and holidays and are most likely to be discontinued on Tuesday or the second day after a holiday. This was probably due to behavioral factors beyond medical indications, requiring further antimicrobial stewardship efforts in the future.
|
発行日 | 2021-10-21
|
出版物タイトル |
Scientific Reports
|
巻 | 11巻
|
号 | 1号
|
出版者 | NATURE PORTFOLIO
|
開始ページ | 20784
|
ISSN | 2045-2322
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © The Author(s) 2021
|
論文のバージョン | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1038/s41598-021-00206-9
|
ライセンス | http://creativecommons.org/licenses/by/4.0/
|
Citation | Honda, H., Hagiya, H., Higashionna, T. et al. Impact of the day of the week on the discontinuation of broad-spectrum antibiotic prescriptions; a multi-centered observational study. Sci Rep 11, 20784 (2021). https://doi.org/10.1038/s41598-021-00206-9
|