| JaLCDOI | 10.18926/bgeou/47111 |
|---|---|
| フルテキストURL | bgeou_147_135_144.pdf |
| 著者 | Mimura, Yukari| Ogura, Toshio| Otsuka, Fumio| |
| 抄録 | Thyroid stimulating hormone receptor antibody (TRAb) plays an important role in Graves' disease (GD). A second-generation measurement system has been developed and we have gotten a benefit by the system clinically. In this study, we determined 4 kinds of TRAb in 42 GD patients using the current and second-generation measurement systems to investigate the differences between them. The secondgeneration measurement system exhibited higher positive rates and inhibition rates of thyroid stimulating hormone (TSH) binding than those of the current system. Furthermore, 42 patients with GD were classified into 4 groups by GD activity. The actual values of all TRAbs and positive rates exhibited a tendency to increase significantly with GD activity. Of significance, 2 TRAbs in the second-generation measurement system exhibited high positive rates. However, all actual values of patients did not necessarily agree with these tendencies. The values of TRAb-human detecting anti-human TSH receptors at an approximate cut-off value reflected GD activity more accurately than those of TRAb-CT detecting anti-porcine TSH receptor. This suggests the possibility of specific differences between TSH receptors and further studies are required to further examine these effects. |
| キーワード | Graves' disease human-TRAb TSAb |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2011-06-25 |
| 巻 | 147巻 |
| 開始ページ | 135 |
| 終了ページ | 144 |
| ISSN | 1883-2423 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120003551002 |
| JaLCDOI | 10.18926/AMO/47015 |
|---|---|
| フルテキストURL | 65_5_329.pdf |
| 著者 | Matsumoto, Yoshinori| Sada, Ken-ei| Takano, Mariko| Toyota, Noriko| Yamanaka, Ryutaro| Sugiyama, Koichi| Wakabayashi, Hiroshi| Kawabata, Tomoko| Otsuka, Fumio| Makino, Hirofumi| |
| 抄録 | It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age≧65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level≧2.0mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR＝4.50, 95%CI＝1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids. |
| キーワード | infection rheumatic disease glucocorticoids interstitial pneumonia risk factors |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 329 |
| 終了ページ | 334 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037270 |
| Web of Science KeyUT | 000296116400007 |
| 著者 | Tsukamoto, Naoko| Otsuka, Fumio| Miyoshi, Tomoko| Inagaki, Kenichi| Nakamura, Eri| Suzuki, Jiro| Ogura, Toshio| Iwasaki, Yasumasa| Makino, Hirofumi| |
|---|---|
| 発行日 | 2011-01-30 |
| 出版物タイトル | Molecular and Cellular Endocrinology |
| 巻 | 332巻 |
| 号 | 1-2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/40128 |
|---|---|
| フルテキストURL | 64_4_213.pdf |
| 著者 | Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Makino, Hirofumi| |
| 抄録 | Aldosterone production occurs in the adrenal cortex, and is regulated primarily by angiotensin II (Ang II), potassium and adrenocorticotropin (ACTH). In the presence of the aldosterone stimulators, steroidogenesis is further governed by local autocrine and/or paracrine factors in the adrenal cortex. We reported the presence of functional bone morphogenetic protein (BMP) system in the adrenal cortex and also demonstrated that BMP-6 increases Ang II-induced aldosterone production, which could be involved in the "aldosterone breakthrough" phenomenon. Aldosterone breakthrough is the phenomenon by which circulating aldosterone concentrations increase above pre-treatment levels after long-term therapy with ACE inhibitors or Ang II type 1 receptor antagonists (ARB). This phenomenon may lead to important clinical consequences since increased aldosterone in a high-salt state facilitates cardiovascular and renal damage in hypertensive patients. We found that long-term ARB treatment reverses the reduction of aldosterone synthesis by adrenocortical cells, thereby causing "cellular aldosterone breakthrough". The availability of BMP-6 in the adrenal cortex may be at least partly involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB. |
| キーワード | adrenal cortex angiotensin II aldosterone bone morphogenetic protein |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 213 |
| 終了ページ | 218 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802537 |
| Web of Science KeyUT | 000281384400001 |
| 著者 | Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Miyoshi, Tomoko| Kano, Yoshihiro| Goto, Junko| Ogura, Toshio| Makino, Hirofumi| |
|---|---|
| 発行日 | 2008-06-25 |
| 出版物タイトル | Endocrinology |
| 巻 | 149巻 |
| 号 | 6号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/30375 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Mimura, Yukari| Ogura, Toshio| Yamauchi, Takayoshi| Otsuka, Fumio| Oishi, Tetsuya| Harada, Kazushi| Hashimoto, Masami| Ota, Zensuke| |
| 抄録 | We recently reported that stimulation of the arginine vasopressin (AVP) V1-receptor enhanced the pressor response in spontaneously hypertensive rats (SHR). In the present study, we investigated acute changes in systolic blood pressure (SBP) and heart rate (HR) after intravenous injections of AVP, OPC-21268 (a V1-receptor antagonist), and OPC-31260 (a V2-receptor antagonist), in anesthetized DOCA-salt hypertensive rats (DOCA) and age-matched sham-operated Wistar rats (control) to determine whether the pressor effect is specific to SHR or is present in other hypertensive animal models. SBP increased significantly in DOCA rats 9 min after injection of AVP 5 ng/kg without a concomitant increase in HR. Neither OPC-21268 3mg/kg nor OPC-31260 3mg/kg caused significant changes in SBP or HR. SBP tended to increase when AVP was administered after injection of OPC-31260. HR increased significantly 15 min after the combined treatment with OPC-31260 and AVP in DOCA rats compared with control rats. SBP did not change significantly when AVP was administered after injection of OPC-21268 in DOCA or control rats, but HR decreased significantly from 1 to 4 min after injection of AVP in DOCA rats. Our results suggest that V1-receptor stimulation does not enhance the pressor response in the DOCA rat, which is a model of volume-dependent hypertension, suggesting that the AVP system, especially V1-receptor, is not as important in the development or maintenance of hypertension in DOCA rats as in SHR. |
| キーワード | vasopressin DOCA-salt hypertensive rat V1-and V2-receptor antagonist spontaneously hypertesive rat(SHR) OPC-21268 |
| Amo Type | Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 1995-08 |
| 巻 | 49巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 187 |
| 終了ページ | 194 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 7502678 |
| Web of Science KeyUT | A1995RR97800002 |
| 著者 | 大谷 寛之| 大塚 文男| 槇野 博史| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 武田 昌也| 大塚 文男| 中村 一文| 稲垣 兼一| 鈴木 二郎| 三浦 大志| 藤尾 栄起| 松原 広己| 伊達 洋至| 大江 透| 槇野 博史| |
|---|---|
| 発行日 | 2006-05-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 118巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大塚 文男| |
|---|---|
| 発行日 | 2007-09-03 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 119巻 |
| 号 | 2号 |
| 資料タイプ | 一般雑誌記事 |
| フルテキストURL | K001796.pdf |
|---|---|
| 著者 | 大塚 文男| |
| 発行日 | 1998-03-31 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第1796号 |
| 学位授与年月日 | 1998-03-31 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |