著者 岡本 章|
発行日 2000-09-10
出版物タイトル 岡山大学経済学会雑誌
32巻
2号
資料タイプ 学術雑誌論文
著者 岡本 章|
発行日 2000-06-10
出版物タイトル 岡山大学経済学会雑誌
32巻
1号
資料タイプ 学術雑誌論文
著者 Okamoto, Akira|
発行日 2005-03-10
出版物タイトル 岡山大学経済学会雑誌
36巻
4号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32814
フルテキストURL fulltext.pdf
著者 Okamoto, Akira| Yamamura, Masahiro| Iwahashi, Mitsuhiro| Aita, Tetsushi| Ueno, Akiko| Kawashima, Masanori| Yamana, Jiro| Kagawa, Hidetoshi| Makino, Hirofumi|
抄録 <p>High levels of soluble CD30 (sCD30) were detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA), indicating the involvement of CD30+ T cells in the pathogenesis. We investigated the induction of CD30 and its functions in CD4+T cells from patients with established RA (disease duration &#62;_2 years). CD4+ T cells from both the peripheral blood (PB) and synovial tissue (ST) of RA patients expressed surface CD30 when stimulated with anti-CD3 antibody (Ab) and anti-CD28 Ab, but their CD30 induction was slower and weaker compared with PB CD4+ T cells of healthy controls (HC). Immunohistochemical analysis showed that only a small proportion of lymphocytes expressed CD30 in the ST (-1%). RA PB CD4+ T cells, after recovery from 6-day stimulation with anti-CD3 Ab and anti-CD28 Ab, showed in intracellular cytokine staining that CD30+ T cells could produce more interleukin-4 (IL-4) but less interferon-gamma. In the culture of RA PB CD4+ T Cells with anti-CD3 Ab and anti-CD28 Ab, blocking anti-CD30 Ab similarly inhibited the cell proliferation and activation of nuclear factor-kappaB on day 4 in RA and HC, but inhibited the apoptotic cell death on day 6 only in RA. These results indicate that despite high-level expression of sCD30, the anti-inflammatory activity of IL-4-producing CD30+ CD4+ T cells may be limited in the ST due to a poor induction of surface CD30 and a susceptibility to CD30-mediated cell death.</p>
キーワード apoptosis CD4 Tcells CD30 interleukin-4(IL=4) rheumatoid arthritis(RA)
Amo Type Article
発行日 2003-12
出版物タイトル Acta Medica Okayama
57巻
6号
出版者 Okayama University Medical School
開始ページ 267
終了ページ 277
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 14726963
Web of Sience KeyUT 000187556500001
著者 岡本 享|
発行日 2003-09-30
出版物タイトル
資料タイプ 学位論文