フルテキストURL Acta_Otolaryngol_137_5_529.pdf Acta_Otolaryngol_137_5_529_image.pdf
著者 Kariya, Shin| Okano, Mitsuhiro| Oto, Takahiro| Higaki, Takaya| Haruna, Takenori| Noda, Yohei| Nishizaki, Kazunori|
抄録 CONCLUSIONS: Chronic rhinosinusitis diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps 2012, not by computed tomography alone, is one of the prognostic factors affecting long-term survival in patients with lung transplantation. Endoscopic sinus surgery might play a beneficial role in the management of lung transplantation recipients with chronic rhinosinusitis. OBJECTIVE: To show the effect of paranasal sinus infection on post-lung transplantation survival. METHOD: Lung transplantation recipients were included in this study. Computed tomography was performed before and after lung transplantation. The severity of chronic rhinosinusitis was evaluated by Lund-Mackay scoring system. The survival rate was calculated by the Kaplan-Meier method. RESULTS: One hundred and forty-eight patients received lung transplantation for various indications. Chronic rhinosinusitis was found in 18.9% (28/148) of the lung transplantation recipients. Of 28 patients with chronic rhinosinusitis, seven patients underwent endoscopic sinus surgery due to persistent post-nasal drip. The recipients with chronic rhinosinusitis who did not receive endoscopic sinus surgery (n = 21) showed a significantly lower survival rate as compared to the patients without chronic rhinosinusitis. There was no statistically significant difference in the survival rate between the recipients with (n = 50) and without (n = 98) paranasal sinus abnormality on computed tomography.
キーワード Lung transplant bronchiolitis obliterans infection; pneumonia survival rate
備考 2018年5月公開予定
発行日 2017-05
出版物タイトル Acta Oto-laryngologica
137巻
5号
出版者 Taylor & Francis
開始ページ 529
終了ページ 533
ISSN 0001-6489
NCID AA0050923X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 27809696
DOI 10.1080/00016489.2016.1247497
Web of Sience KeyUT 000400167100014
関連URL https://doi.org/10.1080/00016489.2016.1247497
フルテキストURL K0005427_other1.pdf
著者 Okano, Mitsuhiro| Fujiwara, Tazuko| Kariya, Shin| Higaki, Takaya| Makihara, Sei-ichiro| Haruna, Takenori| Noyama, Yasuyuki| Koyama, Takahisa| Omichi, Ryotaro| Orita, Yorihisa| Miki, Kentaro| Kanai, Kengo| Nishizaki, Kazunori|
抄録 BACKGROUND: Toll-like receptor 3 (TLR3) is expressed in upper airways, however, little is known regarding whether Toll-like receptor 3 (TLR3) signals exert a regulatory effect on the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), especially on eosinophilic inflammation. We sought to investigate the effect of Poly(IC), the ligand for TLR3, on cytokine production by dispersed nasal polyp cells (DNPCs). METHODS: DNPCs were pretreated with or without Poly(IC), and were then cultured in the presence or absence of staphylococcal enterotoxin B (SEB), following which the levels of IL-5, IL-10, IL-13, IL-17A and interferon (IFN)-γ in the supernatant were measured. To determine the involvement of IL-10 and cyclooxygenase in Poly(IC)-mediated signaling, DNPCs were treated with anti-IL-10 monoclonal antibody and diclofenac, the cyclooxygenase inhibitor, respectively. Poly(IC)-induced prostaglandin E2 (PGE2) production was also determined. RESULTS: Exposure to Poly(IC) induced a significant production of IL-10, but not of IL-5, IL-13, IL-17A or IFN-γ by DNPCs. Pretreatment with Poly(IC) dose-dependently inhibited SEB-induced IL-5, IL-13 and IL-17A, but not IFN-γ production. Neutralization of IL-10 significantly abrogated the inhibitory effect of Poly(IC). Treatment with diclofenac also abrogated the inhibitory effect of Poly(IC) on SEB-induced IL-5 and IL-13 production. However, unlike exposure of diclofenac-treated DNPCs to lipopolysaccharide, the ligand for TLR4, exposure of these cells to Poly(IC) did not enhance IL-5 or IL-13 production. Poly(IC) did not significantly increase PGE2 production by DNPCs. CONCLUSIONS: These results suggest that TLR3 signaling regulates eosinophilia-associated cytokine production in CRSwNP, at least in part, via IL-10 production.
キーワード Chronic rhinosinusitis with nasal polyps IL-10 IL-5 Poly(IC) Toll-like receptor
備考 学位審査副論文
発行日 2016-01
出版物タイトル Allergology international : official journal of the Japanese Society of Allergology
65巻
1号
出版者 Elsevier
開始ページ 96
終了ページ 102
ISSN 1323-8930
NCID AA11091750
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 26666485
Web of Sience KeyUT 000367238600015
関連URL https://doi.org/10.1016/j.alit.2015.08.005 http://ousar.lib.okayama-u.ac.jp/54846
JaLCDOI 10.18926/AMO/54420
フルテキストURL 70_3_205.pdf
著者 Kozaki, Ken-ichi| Kawakami, Shigehisa| Konishi, Takayuki| Ohta, Keiji| Yano, Jitsuro| Onoda, Tomoo| Matsumoto, Hiroshi| Mizukawa, Nobuyoshi| Kimata, Yoshihiro| Nishizaki, Kazunori| Iida, Seiji| Gofuku, Akio| Abe, Masanobu| Minagi, Shogo| Okayama Dream Speech Project|
抄録 A palatal augmentation prosthesis (PAP) is used to facilitate improvement in the speech and swallowing functions of patients with tongue resection or tongue movement disorders. However, a PAPʼs effect is limited in cases where articulation disorder is severe due to wide glossectomy and/or segmental mandibulectomy. In this paper, we describe speech outcomes of a patient with an articulation disorder following glossectomy and segmental mandibulectomy. We used a palatal plate (PP) based on a PAP, along with an artificial tongue (KAT). Speech improvement was evaluated by a standardized speech intelligibility test consisting of 100 syllables. The speech intelligibility score was significantly higher when the patient wore both the PP and KAT than when he wore neither (p=0.013). The conversational intelligibility score was significantly improved with the PP and KAT than without PP and KAT (p=0.024). These results suggest that speech function can be improved in patients with hard tissue defects with segmental mandibulectomy using both a PP and a KAT. The nature of the design of the PP and that of the KAT will allow these prostheses to address a wide range of tissue defects.
キーワード palatal augmentation prosthesis artificial tongue articulation disorder glossectomy mandibulectomy
Amo Type Case Report
発行日 2016-06
出版物タイトル Acta Medica Okayama
70巻
3号
出版者 Okayama University Medical School
開始ページ 205
終了ページ 211
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27339210
Web of Sience KeyUT 000379406100008
著者 片岡 祐子| 西﨑 和則|
発行日 2014-12-01
出版物タイトル 岡山医学会雑誌
126巻
3号
資料タイプ 学術雑誌論文
著者 Sugaya, Akiko| Fukushima, Kunihiro| Kasai, Norio| Ojima, Toshiyuki| Takahashi, Goro| Nakagawa, Takashi| Murai, Seiko| Nakajima, Yasoichi| Nishizaki, Kazunori|
発行日 2014-07
出版物タイトル Annals of Otology, Rhinology & Laryngology
123巻
7号
資料タイプ 学術雑誌論文
著者 Hirai, Misato| Maeda, Yukihide| Fukushima, Kunihiro| Sugaya, Akiko| Kataoka, Yuko| Nishizaki, Kazunori|
発行日 2011-09-14
出版物タイトル NeuroReport
22巻
13号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/52791
フルテキストURL 68_4_249.pdf
著者 Ogawara, Yuya| Tachibana, Tomoyasu| Orita, Yorihisa| Uchino, Kaori| Wani, Yoji| Nagahiro, Itaru| Matsuyama, Yuko| Abe, Iku| Fujisawa, Masayoshi| Nishizaki, Kazunori|
抄録 We describe an extremely rare case of tracheal stenosis caused by unnoticed microscopic fiber-like foreign bodies. A 66-year-old woman complained of dyspnea with inspiratory stridor. Magnifying electroendoscopy and computed tomography revealed stenosis involving the entire circumference of the tracheal lumen. Tracheotomy and biopsy were performed. Histologically, the lesion showed chronic inflammation with a deposition of fiber-like foreign bodies. The patient had no history of trauma or inhalation injury, but had undergone intratracheal intubation on 4 occasions. The lesion was incised using semiconductor laser photoresection, and the postoperative course was good. To the best of our knowledge, this represents the first report in the English literature of tracheal stenosis caused by unnoticed foreign bodies. The origin of these fiber-like foreign bodies remains unclear but might be related to chronic inflammation resulting from intratracheal intubations.
キーワード tracheal stenosis fibrous foreign body intubation tracheotomy laser
Amo Type Case Report
発行日 2014-08
出版物タイトル Acta Medica Okayama
68巻
4号
出版者 Okayama University Medical School
開始ページ 249
終了ページ 252
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145411
Web of Sience KeyUT 000340687500007
著者 Noda, Yohei| Nishizaki, Kazunori| Yoshinobu, Junko| Orita, Yorihisa| Tsujigiwa, Hidetsugu| Yamada, Masao|
発行日 2013-09
出版物タイトル Acta Oto-laryngologica
133巻
9号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/51072
フルテキストURL 67_4_265.pdf
著者 Hanakawa, Hiroyuki| Orita, Yorihisa| Sato, Yasuharu| Uno, Kinya| Nishizaki, Kazunori| Yoshino, Tadashi|
抄録 We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis.
キーワード ulceration methotrexate oropharynx lymphoproliferative disorders
Amo Type Case Report
発行日 2013-08
出版物タイトル Acta Medica Okayama
67巻
4号
出版者 Okayama University Medical School
開始ページ 265
終了ページ 269
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23970326
Web of Sience KeyUT 000323470100009
著者 Higaki, T| Okano, M| Fujiwara, T| Makihara, S| Kariya, S| Noda, Y| Haruna, T| Nishizaki, K|
発行日 2012-08
出版物タイトル Clinical and Experimental Allergy
42巻
8号
資料タイプ 学術雑誌論文
著者 西﨑 和則|
発行日 2012-12-03
出版物タイトル 岡山医学会雑誌
124巻
3号
資料タイプ 一般雑誌記事
著者 片岡 祐子| 福島 邦博| 菅谷 明子| 西﨑 和則|
発行日 2012-08-01
出版物タイトル 岡山医学会雑誌
124巻
2号
資料タイプ 学術雑誌論文
著者 Kawasaki, Akihiro| Fukushima, Kunihiro| Kataoka, Yuko| Fukuda, Shoichiro| Nishizaki, Kazunori|
発行日 2006-8
出版物タイトル International Journal of Pediatric Otorhinolaryngology
70巻
8号
資料タイプ 学術雑誌論文
著者 Kariya, Shin| Nishizaki, kazunori| Akagi, Hirofumi| Paparella, Michael M.|
発行日 2004-11
出版物タイトル Journal of Laryngology & Otology
118巻
11号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32301
フルテキストURL fulltext.pdf
著者 Endo, Ryutaro| Murakami, Shinichiro| Masuda, Yu| Taguchi, Takehito| Ohtsuka, Aiji| Nishizaki, Kazunori| Murakami, Takuro|
抄録 <p>The present study showed that many neurons in the adult rat brain possessed a perineuronal sulfated proteoglycan surface coat which reacted to cationic iron colloid and aldehyde fuchsin. This surface coat was stained supravitally with Ehrlich's methylene blue and doubly stained with Ehrlich's methylene blue and aldehyde fuchsin. The surface coat was also stained with Gomori's ammoniacal silver and doubly stained with Gomori's ammoniacal silver and cationic iron colloid. The surface coat was usually expressed together with a nerve cell surface glycoprotein net detectable with lectin Wisteria floribunda agglutinin. These findings indicate that the perineuronal proteoglycan surface coat is identical to Cajal's superficial reticulum and contains some collagenous elements. It was further demonstrated that collagenase digestion erased Gomori's ammoniacal silver impregnation within the perineuronal proteoglycan surface coat.</p>
キーワード brain extracellular matrix perineuronal proteoglycans cell surface glycoproteins
Amo Type Article
発行日 2000-06
出版物タイトル Acta Medica Okayama
54巻
3号
出版者 Okayama University Medical School
開始ページ 111
終了ページ 118
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10925735
Web of Sience KeyUT 000087965700003
JaLCDOI 10.18926/AMO/30802
フルテキストURL fulltext.pdf
著者 Kimura, Nobuhiko| Nishioka, Keiko| Nishizaki, Kazunori| Ogawa, Teruhiro| Naitou, Yoshihiro| Masuda, Yu|
抄録 <p>&#8195;We studied the clinical efficacy of roxithromycin (RXM) administered at the daily dosage of one tablet (150mg) for 3 months in 30 patients with chronic sinusitis. The effectiveness of this drug was evaluated on a four-point scale. Subjective and objective symptoms disappeared or decreased markedly, especially postnasal drip and nature of discharge in 80 percent or more of the patients. All symptoms significantly decreased (P &#60; 0.001; headache P &#60; 0.05), except for the sensation of foul odor. Symptoms improved even in those cases in which Haemophilus influenzae was detected. It is suggested that RXM produces some clinically beneficial effect through an immunological and or anti-inflammatory mechanisms in addition to its antibiotic effect.</p>
キーワード roxithromycin clinical evaluation chronic sinusitis long-term low-dose administration
Amo Type Article
発行日 1997-02
出版物タイトル Acta Medica Okayama
51巻
1号
出版者 Okayama University Medical School
開始ページ 33
終了ページ 37
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9057933
Web of Sience KeyUT A1997WL24600006
JaLCDOI 10.18926/AMO/30796
フルテキストURL fulltext.pdf
著者 Miyahara, Satoko| Nakada, Michihiro| Nishizaki, Kazunori| Kawarai, Yasuyuki| Nishioka, Keiko| Hino, Hiroo|
抄録 <p>We studied 92 patients with allergic rhinitis in Syodoshima, Japan, during the pollen season between April and June to evaluate the cross-reactivity to different antigens, including pollen from the olive tree (Olea europaea) and orchard grass (Dactylis glomerata). Olive tree pollen was present in the atmosphere for 23 days, from May 19 to June 12, 1994. Specific IgE antibodies for olive tree pollen antigen were present in 21 (26.9%) of the 78 patients with allergic rhinitis. Nine (24.3%) of the 37 patients with allergic rhinitis exhibited positive skin reactivity to an extract of olive tree pollen. Fifteen (88.2 %) of the 17 patients who had IgE reactivity in their sera to olive tree pollen antigen demonstrated allergic reactions to an extract of olive tree pollen. Specific IgE antibodies for orchard grass pollen antigen were present in 43 (48.3%) of the 89 patients with allergic rhinitis and 20 (95.2%) of the 21 patients who had IgE reactivity in their sera to olive tree pollen antigen. The inhibition test using the CAP System revealed that the reactivity of the IgE antibody specific for olive tree pollen antigen was inhibited dose-dependently by an extract of orchard grass pollen. These findings show that there is a reaction in some patients with grass (Gramineae) pollinosis that might be induced by olive tree pollen.</p>
キーワード olive tree pollen pollinosis cross-reactivity grass pollen orchard grass
Amo Type Article
発行日 1997-06
出版物タイトル Acta Medica Okayama
51巻
3号
出版者 Okayama University Medical School
開始ページ 167
終了ページ 171
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9227797
Web of Sience KeyUT A1997XJ12700009
JaLCDOI 10.18926/AMO/30655
フルテキストURL fulltext.pdf
著者 Nishioka, Keiko| Masuda, Yu| Nishizaki, Kazunori| Ogura, Yoshio|
抄録 <p>Unilateral cystic inner ear anomalies were diagnosed in two siblings, a 9 year old boy and a 6 year old girl. X-ray examination of the temporal bone was performed, together with audiological examinations and vestibular function tests. The common tomographic X-ray findings consisted of an enlarged solitary sac type deformity of the vestibule with narrowing of the internal auditory canal, severe hypoplasia of the anterior semicircular canal and no visualized cochlea. Pure-tone audiometry revealed severe mixed type of hearing loss in the right ear in both children. The test for vestibular function showed no response to caloric testing.</p>
キーワード inner ear anomaliy siblings
Amo Type Brief Note
発行日 1982-08
出版物タイトル Acta Medica Okayama
36巻
4号
出版者 Okayama University Medical School
開始ページ 321
終了ページ 324
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7136861
Web of Sience KeyUT A1982PE61100011
JaLCDOI 10.18926/AMO/30373
フルテキストURL fulltext.pdf
著者 Okada, Satoko| Ohtsuka, Aiji| Akagi, Hirofumi| Nishizaki, Kazunori| Masuda, Yu|
抄録 <p>It has previously been confirmed that the guinea pig has aggregations of 10-20 lymphoid follicles at the junction of the nasal cavity and the nasopharyngeal duct. The vascular architecture of this nasal-associated lymphoid tissue (NALT) was studied by the corrosion cast/scanning electron microscope method. The NALT was supplied by branches of the inferior nasal artery. These afferent arterial branches gave off arterioles to the follicles and the interfollicular regions, where the arterioles ramified into capillaries. Some of these arterioles reached the subepithelial region to form a single-layer dense capillary network. The subepithelial capillaries gathered into short collecting venules, which in turn drained into high endothelial venules (HEV) in the interfollicular region. The HEV, which also receives tributaries from the follicular and interfollicular capillary plexuses, descended in the interfollicular regions and finally flowed into the efferent veins at the bottom of the NALT. Indentations impressed by high endothelial cells (HEC) were prominent on the surface of the HEV casts, and their frequency was larger in the upper course or segments than in the lower. This suggests that the incidence of HEC in the upper segments is higher than in the lower segments, and these findings are consistent with the hypothesis that some substances which are taken up into the subepithelial capillaries and transported to the venules induce differentiation and maintain of HEVs.</p>
キーワード nasal-associated lymphoid tisse vascular corrosion cast microvascular architecture high endothelial venule guinea pig
Amo Type Article
発行日 1995-08
出版物タイトル Acta Medica Okayama
49巻
4号
出版者 Okayama University Medical School
開始ページ 213
終了ページ 219
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7502682
Web of Sience KeyUT A1995RR97800006
著者 高原 滋夫| 小倉 義郎| 増田 游| 西岡 慶子| 西崎 和則| 杉浦 友昭| 古川 勝朗| 水河 幸夫| 黒田 泰生| 緒方 正名| 大倉 興司|
発行日 1986-06-30
出版物タイトル 岡山医学会雑誌
98巻
5-6号
資料タイプ 学術雑誌論文