ID | 48707 |
フルテキストURL | |
著者 |
Kataoka, Takahiro
Graduate School of Health Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
Sakoda, Akihiro
Graduate School of Health Sciences, Okayama University
Ishimori, Yuu
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Toyota, Teruaki
Graduate School of Health Sciences, Okayama University
Nishiyama, Yuichi
Graduate School of Health Sciences, Okayama University
Tanaka, Hiroshi
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Yamaoka, Kiyonori
Graduate School of Health Sciences, Okayama University
Kaken ID
publons
researchmap
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抄録 | We examined dose–dependent or dose rate–dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m3 for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m3, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose–rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.
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キーワード | Radon
Superoxide dismutase
Dose
Dose rate
Large-scale facility
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発行日 | 2011-11-22
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出版物タイトル |
Journal of Radiation Research
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巻 | 52巻
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号 | 6号
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出版者 | Journal of Radiation Research Editorial Committee
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開始ページ | 775
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終了ページ | 781
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ISSN | 0449-3060
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NCID | AA00705792
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/jrr/52/6/52_10072/_article
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言語 |
英語
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著作権者 | Copyright © 2011 by Journal of Radiation Research Editorial Committee
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
PubMed ID | |
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