| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Onishi, Yasuhiro| Uchida, Haruhito A.| Maeshima, Yohei| Okuyama, Yuka| Otaka, Nozomu| Ujike, Haruyo| Tanaka, Keiko| Takeuchi, Hidemi| Tsuji, Kenji| Kitagawa, Masashi| Tanabe, Katsuyuki| Morinaga, Hiroshi| Kinomura, Masaru| Kitamura, Shinji| Sugiyama, Hitoshi| Ota, Kosuke| Maruyama, Keisuke| Hiramatsu, Makoto| Oshiro, Yoshiyuki| Morioka, Shigeru| Takiue, Keiichi| Omori, Kazuyoshi| Fukushima, Masaki| Gamou, Naoyuki| Hirata, Hiroshi| Sato, Ryosuke| Makino, Hirofumi| Wada, Jun| |
| キーワード | chronic kidney disease (CKD) medical cooperation patient care team OCKD-NET |
| 発行日 | 2023-03-26 |
| 出版物タイトル | Journal of Personalized Medicine |
| 巻 | 13巻 |
| 号 | 4号 |
| 出版者 | MDPI |
| 開始ページ | 582 |
| ISSN | 2075-4426 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 37108968 |
| DOI | 10.3390/jpm13040582 |
| Web of Science KeyUT | 000977705500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jpm13040582 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tsuchida-Nishiwaki, Mariko| Uchida, Haruhito A.| Takeuchi, Hidemi| Nishiwaki, Noriyuki| Maeshima, Yohei| Saito, Chie| Sugiyama, Hitoshi| Wada, Jun| Narita, Ichiei| Watanabe, Tsuyoshi| Matsuo, Seiichi| Makino, Hirofumi| Hishida, Akira| Yamagata, Kunihiro| |
| 発行日 | 2021-07-22 |
| 出版物タイトル | Scientific Reports |
| 巻 | 11巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 14990 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2021 |
| 論文のバージョン | publisher |
| PubMed ID | 34294784 |
| DOI | 10.1038/s41598-021-94467-z |
| Web of Science KeyUT | 000682802200023 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-021-94467-z |
| JaLCDOI | 10.18926/AMO/52788 |
|---|---|
| フルテキストURL | 68_4_219.pdf |
| 著者 | Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi| |
| 抄録 | Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2. |
| キーワード | chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-08 |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 219 |
| 終了ページ | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25145408 |
| Web of Science KeyUT | 000340687500004 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52824 |
| 著者 | Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi| |
|---|---|
| 発行日 | 2013-02-19 |
| 出版物タイトル | PLoS ONE |
| 巻 | 8巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Takiue, Keiichi| Sugiyama, Hitoshi| Inoue, Tatsuyuki| Morinaga, Hiroshi| Kikumoto, Yoko| Kitagawa, Masashi| Kitamura, Shinji| Maeshima, Yohei| Wang, Dahong| Masuoka, Noriyoshi| Ogino, Keiki| Makino, Hirofumi| |
|---|---|
| 発行日 | 2012-05-25 |
| 出版物タイトル | BMC Nephrology |
| 巻 | 13巻 |
| 号 | 14号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 那須 達世| 前島 洋平| 木野村 賢| 川原（広越） 久美子| 田邊 克幸| 杉山 斉| 園田 光| 佐藤 靖史| 槇野 博史| |
|---|---|
| 発行日 | 2011-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/31820 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Miyake, Kohei| Nishida, Keiichiro| Kadota, Yasutaka| Yamasaki, Hiroko| Nasu, Tatsuyo| Saitou, Daisuke| Tanabe, Katsuyuki| Sonoda, Hikaru| Sato, Yasufumi| Maeshima, Yohei| Makino, Hirofumi| |
| 抄録 | Angiogenesis is an essential event in the development of synovial inflammation in rheumatoid arthritis (RA). The aim of the current study was to investigate the expression of vasohibin-1, a novel endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor, in the RA synovium, and to test the effect of inflammatory cytokines on the expression of vasohibin-1 by RA synovial fibroblasts (RASFs). Synovial tissue samples were obtained at surgery from patients with osteoarthritis (OA) and RA, and subjected to immunohistochemistry to investigate the expression and distribution of vasohibin-1 relevant to the degree of synovial inflammation. In an in vitro analysis, RASFs were used to examine the expression of vasohibin-1 and VEGF mRNA by real-time PCR after stimulation with VEGF or inflammatory cytokines under normoxic or hypoxic conditions. The immunohistochemical results showed that vasohibin-1 was expressed in synovial lining cells, endothelial cells, and synovial fibroblasts. In synovial tissue, there was a significant correlation between the expression of vasohibin-1 and histological inflammation score (p0.002, r0.842). In vitro, stimulation with VEGF induced the expression of vasohibin-1 mRNA in RASFs under normoxic conditions, and stimulation with cytokines induced vasohibin-1 mRNA expression under a hypoxic condition. These results suggest that vasohibin-1 was expressed in RA synovial tissue and might be regulated by inflammatory cytokines. |
| キーワード | angiogenesis vasohibin-1 rheumatoid arthritis synovial membrane VEGF |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2009-12 |
| 巻 | 63巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 349 |
| 終了ページ | 358 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20035291 |
| Web of Science KeyUT | 000273145900006 |
| 著者 | 前島 洋平| |
|---|---|
| 発行日 | 1997-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |