著者 | 谷口 暁| 宮原 信明| 中原 淳| 高田 三郎| 佐久川 亮| 長野 修| 谷本 安| 金廣 有彦| 木浦 勝行| 氏家 良人| 谷本 光音| |
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発行日 | 2011-12-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 123巻 |
号 | 3号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/46635 |
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フルテキストURL | 65_3_215.pdf |
著者 | Waseda, Koichi| Tanimoto, Yasushi| Hasegawa, Kenjiro| Miyahara, Nobuaki| Nojima, Daisuke| Ikeda, Genyo| Kanehiro, Arihiko| Okada, Chiharu| Kimata, Yoshihiro| Tanimoto, Mitsune| |
抄録 | Churg-Strauss syndrome (CSS) is a granulomatous necrotizing vasculitis of unknown etiology associated with bronchial asthma. Despite affecting small to medium-sized vessels, necrosis of the digits due to vasculitis is extremely rare. We report a case of CSS with necrosis of the toe tips. A 37-year-old woman with asthma, who had been diagnosed with CSS 2 years ago, was admitted to our hospital with an exacerbation of CSS. The patient had a high grade fever and complained of abdominal pain and numbness of the lower extremities. Blood examination revealed marked eosinophilia. The fever pattern, abdominal pain and blood eosinophilia showed improvement by combination treatment with prednisolone and cyclophosphamide. However, the color of her right toe tips changed, and necrosis finally resulted despite antithrombotic therapy. Arteriography showed narrowing of the dorsalis pedis artery and of the more peripheral arteries of her right leg. Stump plasty with negative pressure dressing therapy for the toe tips, but not amputation, was done to preserve the leg function. While numbness of the extremities remained, no recurrence of necrosis was seen. Clinicians need to be aware that rare complications of CSS, including necrosis of the digits, can occur. |
キーワード | bronchial asthma Churg-Strauss syndrome eosinophilia necrosis of toe tips stump plasty |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-06 |
巻 | 65巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 215 |
終了ページ | 218 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 21709721 |
Web of Science KeyUT | 000292017500010 |
JaLCDOI | 10.18926/AMO/32852 |
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フルテキストURL | fulltext.pdf |
著者 | Iio, Kouji| Iio, Tomoe Ueno| Okui, Yuhei| Ichikawa, Hirohisa| Tanimoto, Yasushi| Miyahara, Nobuaki| Kanehiro, Arihiko| Tanimoto, Mitsune| Nakata, Yasunari| Kataoka, Mikio| |
抄録 | Propionibacterium acnes has been implicated as an etiologic agent of sarcoidosis since the isolation of this bacterium from sarcoid lesions. We experimentally produced a murine pulmonary granuloma model using P. acnes with several features that simulate sarcoidosis. Mice were sensitized with heat-killed P. acnes and complete Freund's adjuvant and were subsequently challenged with heat-killed P. acnes at 2-week intervals. P. acnes-challenged mice developed epitheloid cell granulomas in the lungs. These mice showed a pulmonary immune response characterized by an increased number of T-lymphocytes, especially CD4 cells, and the ratio of CD4/CD8 in bronchoalveolar lavage (BAL) fluid also increased. Furthermore, significant elevations in both angiotensin-converting enzyme (ACE) serum levels and antibody titers against P. acnes were observed. Mice sensitized with P. acnes without complete Freund's adjuvant were capable of forming pulmonary granulomas, which appeared to be caused by indigenous P. acnes. The genome of P. acnes was found in the lungs, BAL cells, hilar lymph nodes, liver, and spleen in non-sensitized mice, which were thought to be germ-free. These results suggest that the immune response against indigenous P. acnes may play an important role in the pathogenesis of granuloma formation in a murine model. |
キーワード | Propionibacterium acnes experimental granuloma sarcoidosis |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2010-04 |
巻 | 64巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 75 |
終了ページ | 83 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 20424662 |
Web of Science KeyUT | 000276996900001 |
JaLCDOI | 10.18926/AMO/32272 |
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フルテキストURL | fulltext.pdf |
著者 | Miyahara, Nobuaki| Eda, Ryosuke| Takeyama, Hiroyasu| Kunichika, Naomi| Moriyama, Michihiko| Aoe, Keisuke| Kohara, Hiroyuki| Chikamori, Kenichi| Maeda, Tadashi| Harada, Mine| |
抄録 | Although the rehabilitation of patients with chronic obstructive pulmonary disease (COPD) improves both exercise capacity and quality of life, a standard protocol for COPD patients has not been established. To clarify whether physiologic and quality-of-life improvements can be achieved by an inpatient pulmonary rehabilitation program 5 days per week for 3 weeks, 18 patients with COPD were enrolled in a rehabilitation program. The physical exercise training regimen consisted of respiratory muscle stretch gymnastics and cycle ergometer exercise training. Pulmonary function tests, an incremental ergometer exercise test, a 6-min walking test, and a quality of life assessment by the Chronic Respiratory Questionnaire were administered before and after the program. The peak VO2, an indicator of maximal exercise capacity, did not increase, although the 6-min walking distance, an indicator of functional exercise capacity, increased significantly after rehabilitation. There was a significant improvement in the quality of life in terms of dyspnea, fatigue, and emotional state. These findings suggest that even a 3-week program may be beneficial for COPD patients. Increases in functional exercise capacity, even without an increase in maximal exercise capacity, are helpful for reducing dyspnea and improving quality of life parameters in patients with COPD. |
キーワード | exercise tolerance stretch gymnastic dyspnea |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2000-08 |
巻 | 54巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 179 |
終了ページ | 184 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 10985178 |
Web of Science KeyUT | 000089132800006 |
著者 | 宮原 信明| |
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発行日 | 1994-08 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 106巻 |
号 | 7-8号 |
資料タイプ | 学術雑誌論文 |
著者 | 宮原 信明| |
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発行日 | 1994-12-31 |
出版物タイトル | |
資料タイプ | 学位論文 |