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ID 52020
フルテキストURL
著者
Matsubara, Minoru Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Shiraha, Hidenori Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Kataoka, Jyunro Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Iwamuro, Masaya Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Horiguchi, Shigeru Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Nishina, Shin-ichi Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Takaoka, Nobuyuki Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Uemura, Masayuki Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Takaki, Akinobu Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Nakamura, Shinichiro Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Kobayashi, Yoshiyuki Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Nouso, Kazuhiro Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
Yamamoto, Kazuhide Okayama Univ Grad Sch Med & Dent, Dept Gastroenterol & Hepatol
抄録
Background and Aim: Hepatocellular carcinoma (HCC) is a hypervascular tumor, and angiogenesis plays an important role in its development. Previously, we demonstrated that des-gamma-carboxyl prothrombin (DCP) promotes both cell proliferation and migration of human umbilical vein endothelial cells (HUVECs) by inducing the autophosphorylation of kinase insert domain receptor (KDR). In the present study, DCP-associated tumor angiogenesis was assessed by comparing hypovascular and common hypervascular HCC. Methods: The solitary HCCs of 827 patients were classified into two groups according to the tumor density at the arterial phase of a dynamic computed tomography scan; the initial clinical data of patients with the hyper- and hypovascular types were compared. The HCC tissues from 95 tumors were analyzed by immunohistochemical staining for DCP and phosphorylated KDR, and intratumoral microvessel density (MVD) was analyzed to evaluate microvessel angiogenesis. Results: The serum DCP levels (320 +/- 3532 mAU/mL) and tumor size (18.4 +/- 9.0 mm) of patients with hypervascular HCC were significantly greater than those with hypovascular HCC (38.7 +/- 80 mAU/mL and 14.6 +/- 5.2 mm, P < 0.001). Immunohistochemical analysis revealed that the expressions of DCP and phospho-KDR were significantly greater in hypervascular HCC (71.4% and 31.0%, respectively) than in hypovascular HCC (7.6% and 5.7%, respectively). Intratumoral MVD was significantly correlated with DCP (r = 0.48, P < 0.0001). Conclusions: des-gamma-carboxyl prothrombin production is associated with tumor angiogenesis in HCC.
キーワード
des-gamma-carboxyl prothrombin
hepatocellular carcinoma
intratumoral microvessel density
kinase insert domain receptor
発行日
2012-10
出版物タイトル
Journal of Gastroenterology and Hepatology
27巻
10号
開始ページ
1602
終了ページ
1608
ISSN
0815-9319
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1111/j.1440-1746.2012.07173.x
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51951
言語
English
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT