ID | 30419 |
JaLCDOI | |
フルテキストURL | |
著者 |
Yamauchi, Takayoshi
Okayama University
Oishi, Tetsuya
Okayama Univresity
Harada, Kazushi
Okayama University
Hashimoto, Masami
Okayama University
Asano, Naoko
Okayama University
Ota, Zensuke
Okayama University
|
抄録 | To elucidate the effect of the arginine vasopressin (AVP) system in vivo, especially V1 and V2 activity, on blood pressure, we measured the acute changes in blood pressure and heart rate after AVP, OPC-21,268 (a V1 receptor antagonist), and OPC-31,260 (a V2 receptor antagonist) were injected intravenously in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at the age of 15 weeks. Compared with the control period, single injection of AVP 5 ng/kg significantly increased systolic blood pressure in WKY rats without a concomitant increase in heart rate, but there was no significant increase in blood pressure in SHR. In contrast, single injection of either OPC-21,268 3 mg/kg or OPC-31,260 3 mg/kg did not affect blood pressure or heart rate in either SHR or WKY rats. Injection of AVP after the administration of OPC-31,260 induced a greater increase in blood pressure in SHR than in WKY rats, whereas injection of AVP after the administration of OPC-21,268 did not induce any clear increase in blood pressure in SHR or WKY rats. These results suggest that SHR have enhanced pressor activity mediated by V1 receptors and that this increase may be due to an increase in their number. In conclusion, enhancement of V1 activity may contribute to the development of high blood pressure in SHR. |
キーワード | vasopressin
V1 and V2 receptor antagonist
hypertension
pressor response
OPC-31260
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1995-02
|
巻 | 49巻
|
号 | 1号
|
出版者 | Okayama University Medical School
|
開始ページ | 53
|
終了ページ | 59
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |