ID | 65486 |
フルテキストURL | |
著者 |
Takata, Jun
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kiura, Katsuyuki
Department of Allergy and Respiratory Medicine, Okayama University Hospital
ORCID
Kaken ID
publons
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Nakasuka, Takamasa
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Hirabae, Atsuko
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Arimoto-Kobayashi, Sakae
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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抄録 | We investigated the chemopreventive effects of beer, nonalcoholic beers (NABs), and beer-components (glycine betaine (GB)) on NNK-induced lung tumorigenesis in A/J mice, and the possible mechanisms underlying the antitumorigenic effects of beer, NABs, and beer-components. Beer, NABs, and GB reduced NNK-induced lung tumorigenesis. We investigated the antimutagenicity of beer, NABs and beer-components (GB and pseudouridine (PU)) toward the mutagenicity of 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Beer, NABs, and beer components were antimutagenic toward MNNG and NNK in the Ames test using S. typhimurium TA1535. In contrast, MNNG and NNK mutagenicity detected in S. typhimurium YG7108, a strain lacking O-6-methylguanine DNA methyltransferases (ogt(ST) and ada(ST)) did not decrease in the presence of beer, NABs, or beer components, suggesting that they may mediate its antimutagenic effect by enhancing DNA damage repair. Phosphorylation of Akt and STAT3, with or without epidermal growth factor stimulation, in lung epithelial-like A549 cells were significantly decreased following beer, NABs, GB and PU. They targeted both the initiation and growth/progression steps of carcinogenesis, specifically via antimutagenesis, stimulation of alkyl DNA-adduct repair, and suppression of Akt- and STAT3- mediated growth signaling. GB and PU may contribute, in part, to the biological effects of beer and NABs via the suppression of Akt and STAT3 phosphorylation.
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キーワード | Anti-mutagenesis
Signal transduction
Lung tumorigenesis
DNA methylation
Tobacco-specific nitrosamine
Glycine betaine
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備考 | The version of record of this article, first published in Genes and Environment, is available online at Publisher’s website: http://dx.doi.org/10.1186/s41021-023-00276-3
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発行日 | 2023-06-07
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出版物タイトル |
Genes and Environment
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巻 | 45巻
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号 | 1号
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出版者 | BMC
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開始ページ | 19
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ISSN | 1880-7046
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © The Author(s) 2023.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
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関連URL | isVersionOf https://doi.org/10.1186/s41021-023-00276-3
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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Citation | Takata, J., Kiura, K., Nakasuka, T. et al. Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice. Genes and Environ 45, 19 (2023). https://doi.org/10.1186/s41021-023-00276-3
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