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ID 31552
JaLCDOI
フルテキストURL
著者
Yonei, Toshiro National Okayama Hospital
Ohnoshi, Taisuke Okayama University
Hiraki, Shunkichi Okayama Red Cross Hospital
Ueoka, Hiroshi Okayama University
Kiura, Katsuyuki Okayama University
Moritaka, Tomonori Okayama University
Shibayama, Takuo Okayama University
Tabata, Masahiro Okayama University
Segawa, Yoshihiko Okayama University
Takigawa, Nagio Okayama University
Kimura, Ikuro Okayama University
抄録

Antitumor activities of five platinum analogs, including cisplatin, carboplatin, 254-S, DWA2114R, and NK121, were compared using five human lung cancer cell lines and 19 tumor specimens obtained from lung cancer patients. The antitumor activity was evaluated by determining the ratio of the maximum tolerated dose of each drug to the 70% tumor growth inhibitory concentration in a colony assay. Cisplatin was the most potent agent, followed by 254-S and carboplatin. DWA2114R and NK121 were less potent than cisplatin and 254-S. Cross-resistance to adriamycin was also investigated using an adriamycin-resistant small cell lung cancer subline, SBC -3/ADM30. SBC-3/ADM30 was 1.7- to 4.0-fold more resistant to cisplatin, carboplatin, NK121, and DWA2114R, than was the parent line, SBC-3, and the subline was 2.0-fold more sensitive to 254-S. Using SBC-3, in vitro combination effects of etoposide and cisplatin, carboplatin, or 254-S were evaluated by the median-effect principle. Synergism was noted when cisplatin and etoposide were combined at a fixed molar ratio of 1:1. Combination of carboplatin and etoposide showed an additive effect. The combination of 254-S and etoposide was antagonistic at low concentrations, but was markedly synergistic at higher concentrations. These data suggested the efficacy of 254-S in the treatment of lung cancer.

キーワード
platinum analogs
antitumor activity
lung cancer
colony assay
combination effect
Amo Type
Article
発行日
1993-08
出版物タイトル
Acta Medica Okayama
47巻
4号
出版者
Okayama University Medical School
開始ページ
233
終了ページ
241
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT