ID | 30470 |
JaLCDOI | |
フルテキストURL | |
著者 |
Watanabe, Kazuhide
Okayama University
Matsuka, Naoyuki
Okayama University
Furuno, Katushi
Okayama Univeristy
Eto, Kohei
Okayama University
Gomita, Yutaka
Okayama University
|
抄録 | In order to evaluate a clinical use of omeprazole suspension, we examined the pharmacokinetics of omeprazole after oral administration in rats. Although the administration of omeprazole suspension buffered by NaHCO3 solution did not produce a significant increase in the area under the concentration-time curve (AUC) value compared with non-buffered group, the administration of NaHCO3 buffer immediately after dosing of omeprazole suspension buffered by NaHCO3 caused a significant increase in the AUC value. These results suggest that the NaHCO3 treatment following the administration of omeprazole buffered suspension effectively decreased the degradation of the compound by gastric acid. Therefore, the successive administration of NaHCO3 solution after the omeprazole dosing seems to be a simple and useful method for the administration to patients who cannot receive tablets. |
キーワード | omeprazole
suspension
pharmacokinetics
rats
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1996-08
|
巻 | 50巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 219
|
終了ページ | 222
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |