ID | 51443 |
フルテキストURL | |
著者 |
Tayra, Judith Thomas
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Kameda, Masahiro
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Kaken ID
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Yasuhara, Takao
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
ORCID
Kaken ID
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Kadota, Tomohito
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Wang, Feifei
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Kikuchi, Yoichiro
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Liang, Hanbai
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Shinko, Aiko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Wakamori, Takaaki
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Vcelar, Brigitta
Polymun Sci GmbH
Weik, Robert
Polymun Sci GmbH
Date, Isao
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
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抄録 | Parkinson's disease is characterized by progressive degeneration of dopaminergic neurons. Thus the development of therapeutic neuroprotection and neurorescue strategies to mitigate disease progression is important. In this study we evaluated the neuroprotective/rescue effects of erythropoietin Fc fusion protein (EPO-Fc) and carbamylated erythropoietin Fe fusion protein (CEPO-Fc) in a rat model of Parkinson's disease. Adult female Sprague-Dawley rats received intraperitoneal injection of EPO-Fc, CEPO-Fc or PBS. Behavioral evaluations consisted of rota-rod, cylinder and amphetamine-induced rotation tests. In the neuroprotection experiment, the CEPO-Fc group demonstrated significant improvement compared with the EPO-Fc group on the amphetamine-induced rotation test throughout the four-week follow-up period. Histologically, significantly more tyrosine hydroxylase (TH)-positive neurons were recognized in the substantia nigra (SN) pars compacta in the CEPO-Fc group than in the PBS and EPO-Fc groups. In the neurorescue experiment, rats receiving CEPO-Fc showed significantly better behavioural scores than those receiving PBS. The histological data concerning striatum also showed that the CEPO-Fc group had significantly better preservation of TH-positive fibers compared to the PBS and EPO-Fc groups. Importantly, there were no increases in hematocrit or hemoglobin levels in the CEPO-Fc group in either the neuroprotection or the neurorescue experiments. In conclusion, the newly developed CEPO-Fc might confer neuroprotective and neurorescue benefits in a rat model of Parkinson's disease without the side effects associated with polycythemia. CEPO-Fc might be a therapeutic tool for patients with Parkinson's disease.
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キーワード | Carbamylated erythropoietin
Dopamine
Neuroprotection
Neurorescue
Parkinson's disease
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発行日 | 2013-03-28
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出版物タイトル |
Brain Research
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巻 | 1502巻
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出版者 | Elsevier Science Bv
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開始ページ | 55
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終了ページ | 70
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ISSN | 0006-8993
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://dx.doi.org/10.1016/j.brainres.2013.01.042
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/51453
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言語 |
英語
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著作権者 | (C) 2013 Elsevier B.V. All rights reserved.
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |