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ID 14021
Eprint ID
14021
フルテキストURL
Thumnail 105_291.pdf 1.18 MB
タイトル(別表記)
The effect of hyperbaric oxygen on lipid peroxidation, antioxidant activity and guanidines and amino acids metabolism in rat brain
著者
伊藤 武彦 岡山大学医学部附属分子細胞医学研究施設神経情報学部門
抄録
Lipid peroxidation, free radical contents, antioxidant activity, guanididno compound metabolism and changes in amino acid contents in rat brain were studied to clarify the effect of a clinically relevant dose of hyperbaric oxygen (HBO). Seven-week-old rats were exposed to HBO at 3 atmosphere absolute for 2 hours. An increase in thiobarbituric acid reactive substances and carbon centered radicals was observed after exposure. Supreoxide dismutase-like activity also increased. The measurement of guanidino compounds revealed a significant rise in arginine and guanidinoacetic acid (GAA) levels. Since arginase activity decreased while there was no significant alteration in arginine : glycine-amidinotransferase activity, these changes in enzyme activities seem to cause the increase of arginine and GAA levels. In relation to guanidino compound metabolism, the amino acid contents were determined. An increase in glutamine and taurine levels were observed and these seemed to favor the defense mechanism. These data suggested that ongoing lipid peroxidation in the brain was caused by HBO, and that the defense mechanism against the oxidative stress was activated in response.
キーワード
hyperbaric oxygen
lipid peroxidation
antioxidants
guanidino compounds
amino acids
発行日
1993
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
105巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
291
終了ページ
302
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/105/3-4/105_3-4_291/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma