| 著者 | Shien, Kazuhiko| Toyooka, Shinichi| Ichimura, Kouichi| Soh, Junichi| Furukawa, Masashi| Maki, Yuho| Muraoka, Takayuki| Tanaka, Norimitsu| Ueno, Tsuyoshi| Asano, Hiroaki| Tsukuda, Kazunori| Yamane, Masaomi| Oto, Takahiro| Kiura, Katsuyuki| Miyoshi, Shinichiro| |
|---|---|
| 発行日 | 2012-07 |
| 出版物タイトル | Lung Cancer |
| 巻 | 77巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/49253 |
|---|---|
| フルテキストURL | 67_1_19.pdf |
| 著者 | Furukawa, Masashi| Soh, Junichi| Yamamoto, Hiromasa| Ichimura, Kouichi| Shien, Kazuhiko| Maki, Yuho| Muraoka, Takayuki| Tanaka, Norimitsu| Ueno, Tsuyoshi| Asano, Hiroaki| Tsukuda, Kazunori| Toyooka, Shinichi| Miyoshi, Shinichiro| |
| 抄録 | Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas. We examined NFKBIA expression, mutations in the EGFR and K-ras genes, and EML4-ALK fusion in 101 resected lung adenocarcinoma samples from never-smokers. NFKBIA expression was evaluated using immunohistochemistry. NFKBIA expression was negative in 16 of the 101 samples (15.8%). EGFR and K-ras mutations and EML4-ALK fusion were detected in 61 (60.5%), 1 (1.0%), and 2 (2.0%) of the 101 samples, respectively, in a completely mutually exclusive manner. Negative NFKBIA expression was observed significantly more frequently among the tumors with none of the three genetic alterations compared to those with such alterations (p＝0.009). In addition, negative NFKBIA expression was significantly more frequent among the EGFR-wild type samples compared to the EGFR-mutant samples (p＝0.013). In conclusion, NFKBIA expression was silenced in adenocarcinomas without EGFR/K-ras mutations or EML4-ALK fusion, suggesting that the silencing of NFKBIA may play an important role in the carcinogenesis of adenocarcinomas independent of EGFR/K-ras mutations or EML4-ALK fusion. |
| キーワード | never-smoker lung cancer adenocarcinoma nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α epidermal growth factor receptor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 19 |
| 終了ページ | 24 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439505 |
| Web of Science KeyUT | 000316829900003 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52534 |
| JaLCDOI | 10.18926/AMO/45273 |
|---|---|
| フルテキストURL | 65_2_135.pdf |
| 著者 | Matsuo, Toshihiko| Himei, Kengo| Ishii, Keita| Ichimura, Kouichi| Yanai, Hiroyuki| Nose, Soichiro| Mimura, Tetsushige| |
| 抄録 | An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with noradrenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Arg167Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cerebellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma. |
| キーワード | retinal (papillary, optic disc) hemangioma von Hippel-Lindau disease pheochromocytoma pancreatic neuroendocrine tumor external beam radiation (radiotherapy) |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-04 |
| 巻 | 65巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 135 |
| 終了ページ | 141 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21519372 |
| Web of Science KeyUT | 000289818800010 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yano, Masaaki| Ouchida, Mamoru| Shigematsu, Hisayuki| Tanaka, Noriyoshi| Ichimura, Koichi| Kobayashi, Kazuyasu| Inaki, Yasuhiko| Toyooka, Shinichi| Tsukuda, Kazunori| Shimizu, Nobuyoshi| Shimizu, Kenji| |
| キーワード | alternative splicing HELLS loss of heterozygosity lung cancer SMARCA6 |
| 備考 | Digital Object Identifer:10.1002/ijc.20407 Published with permission from the copyright holder. This is the author's copy, as published in the Journal of International Journal of Cancer, October 2004, Volume 112, Issue 1, Pages 8-13. Publisher URL:http://dx.doi.org/10.1002/ijc.20407 Direct access to Thomson Web of Science record Copyright © 2004 Wiley-Liss, Inc. All rights reserved.| |
| 発行日 | 2004-10-20 |
| 出版物タイトル | International Journal of Cancer |
| 巻 | 112巻 |
| 号 | 1号 |
| 出版者 | Wiley-Liss, Inc. |
| 開始ページ | 8 |
| 終了ページ | 13 |
| ISSN | 0020-7136 |
| NCID | AA00680002 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | Wiley-Liss, Inc. |
| 論文のバージョン | author |
| PubMed ID | 15305370 |
| DOI | 10.1002/ijc.20407 |
| Web of Science KeyUT | 000223939100002 |
| JaLCDOI | 10.18926/AMO/32097 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Koirala, Tirtha Raj| Hayashi, Kazuhiko| Jin, Zaishun| Onoda, Sachiyo| Tanaka, Takehiro| Oda, Wakako| Ichimura, Koichi| Ohara, Nobuya| Oka, Takashi| Yamada, Masao| Yoshino, Tadashi| |
| 抄録 | Epstein-Barr virus (EBV)-related herpesvirus (Si-IIA-EBV) was serially transmitted for 3 passages from rabbit to rabbit of the opposite sex by blood transfusion, which subsequently induced virus-associated rabbit lymphomas. The virus could be transmitted by transfusion with 15-20 ml of whole blood (7/7) or irradiated blood (1/6) from the EBV-related virus-infected rabbits, but there was no transmission with transfusion of cell-free plasma (0/6) from the infected rabbits. Passive anti-EBV-VCA IgG (x 20 approximately x 10) titers decreased during the first 1-2 weeks in the transfused rabbits. The virus-transmitted rabbits showed a gradual increase in antibody titers ranging from peak titers of x 640 to x 2560 after 3 weeks of transfusion. The recipient origin of malignant lymphoma that developed in the first rabbit transfused by infected blood was confirmed by chromosomal analysis. This rabbit model thus shows that EBV-related herpesvirus is serially transmissible by blood transfusion and that transmission can not be completely prevented by irradiation of blood, but removal of blood cells is the best way to prevent transmission of EBV-related virus. Therefore, this animal model provides a convenient in vivo system for studies of the prevention and therapy of transfusion-related transmission of EBV and EBV-associated lymphoproliferative diseases in immunocompromised human beings. |
| キーワード | ?Epstein-Barr virus(EBV) rabbit lymphoproliferative diseases blood transfusion |
| Amo Type | Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2004-04 |
| 巻 | 58巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 67 |
| 終了ページ | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 15255507 |
| Web of Science KeyUT | 000221043700002 |
| 著者 | 市村 浩一| |
|---|---|
| 発行日 | 2001-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |